Diabetic nephropathy in insulin-dependent diabetic patients: renal hemodynamics and derived treatment strategies
Ter Wee, P.M.; Donker, J.M.
Journal of Diabetic Complications 3(2): 62-69
ISSN/ISBN: 0891-6632 PMID: 2526142 DOI: 10.1016/0891-6632(89)90014-7
Late complications such as retinopathy and neuropathy contribute substantially to the morbidity of patients with diabetes mellitus but have only moderate effect on their life expectancy. However, once diabetic nephropathy occurs, life expectancy of patients with diabetes mellitus is shortened considerably. This review discusses briefly several possible pathogenetic mechanisms involved in the development of diabetic nephropathy. Changes in renal hemodynamics as the initiating and contributing factor to the development of diabetic nephropathy are discussed in more detail. Finally, the article reviews possible therapeutic measures to prevent the development of diabetic nephropathy, or to slow down its progression.