+ Translate

Diamide acts intracellularly to enhance transmitter release: the differential permeation of diamide, DIP, DIP+1 and DIP+2 across the nerve terminal membrane

, : Diamide acts intracellularly to enhance transmitter release: the differential permeation of diamide, DIP, DIP+1 and DIP+2 across the nerve terminal membrane. Brain Research 117(2): 277-285

The actions of the new potent thiol oxidizing agents, diazene dicarboxylic acid bis (N'-methyl piperazide) (DIP) and the N'-methyl iodide (DIP + 1) and the bis-N'-methyl iodide (DIP + 2) salts of DIP, were tested at the frog neuromuscular junction. At 20 degrees C, DIP was as fast as the thiol oxidizing agent, diamide, in evoking transmitter release but was appreciably less effective at 6 degrees C. DIP + 1 and DIP + 2 did not increase transmitter release. Since the three agents are potent oxidizers of glutathione and since the effectiveness of the compounds appears to depend on their ability to exist, at least in part, in a neutral form at physiological pH, it is concluded that their action as promoters of transmitter release depends on their ability to permeate nerve terminal membranes. Thus, both diamide and DIP act to increase transmitter release by the intracellular oxidation of glutathione. The two charged agents, DIP + 1 and DIP + 2, are potent muscular depolarizing agents. It is probable that the quaternary nitrogen groups of these compounds render them cholinomimetics.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 039814436

PMID: 990916

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Ampuero Ramos, L. A., 1981: The Bolivian beef cattle industry: effects of transportation projects upon plant location and product flows in Beni. The study examines what will happen with the optimal location patterns of new slaughterhouses in Beni and factor product flows as the new transportation connections are completed. The criterion of optimality selected in the analysis is the minimum...

Kairiukstis, L.; Grigaliunas, J.; Skuodiene, L.; Stravinskiene, V., 1987: Physiological and dendrochronological indications of forest decline and their application for monitoring. By integrating the results of studies on the physiological state of trees in the initial stage of pollution damage, the dynamics of radial tree increment, and the evaluation of tree height increment, it is concluded that measurements of potassium...

Romero Carranza E.; Galvan Rodriguez F.D.; Alarcon J.A.; Jimenez Izquierdo M.D.; Lopez Lopez H.M., 1980: Prevention of a possible outbreak of human rabies transmitted by bats. Revista Latinoamericana de Microbiologia 22(1): 53

Rothstein, Robert W.; Hai, Chi Ming, 1998: Receptor-mediated nitric oxide release is dependent on pH in bovine newborn pulmonary vascular smooth muscle. Pediatric Research 43(4 PART 2): 296A, April

Gum Justin; Burtt Andrew, 2000: Environmental risk assessment of the Dawesley-Bremer catchment; effects of the Brukunga pyrite mine. MESA Journal 19: 20-21

Bisson, M. A.; Kirst, G. O., 1980: Lamprothamnium papulosum a eury haline charophyte 2. time course of turgor regulation. Changes in the concentrations of K+ and Cl- in the euryhaline charophyte, L. papulosum (Wallr.) J. Gr. occur in parallel during turgor regulation, and account for the changes in osmotic pressure. Thus, it is impossible to single out one ion whose...

Arata, J., 1976: An unusual hair follicle tumor-an intimate relative of trichogenic adnexal tumor (Headington and French). Journal of Dermatology 3(5): 221-229

Auezov, E.M., 1971: Taxonomic evaluation and systematic status of Larus relictus. Zool ; 50: 235-242

Velez, Eduardo.; Menegheti, Joao O.; Schwarzbold, Albano., 1998: Relationships between waterbirds and wetlands in the west coastal plain, southern Brazil: methodology of wetland sampling design. Internationale Vereinigung fuer Theoretische und Angewandte Limnologie Verhandlungen. Juni; 265: 2347-2349

Anonymous, 1976: Xth International symposium on fruit tree virus diseases 1976 Heidelberg. The following papers were presented: Myrobalan latent ring spot, a bipartite genome virus and a strain of tomato black ring virus, by J. Dunez and R. Delbos; The possible epidemiological significance of pollen and seed transmission in the cherry l...