+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Diet, liver function and dimethylhydrazine-induced gastrointestinal tumours in male Wistar rats

Diet, liver function and dimethylhydrazine-induced gastrointestinal tumours in male Wistar rats

British Journal of Cancer 39(6): 731-739

Male Wistar rats fed a normal laboratory pelleted diet, when treated s.c. with 1,2-dimethylhydrazine (DMH) 10 mg/kg/wk survived the 24-week experiment, showed no signs of chemical toxicity or macroscopic liver damage, and developed mainly large-bowel tumours. Conversely, male Wistar rats treated with 20 mg/kg/wk DMH did not survive the full term of the experiment and developed ascites, pleural effusions and nodular livers. They also developed more small-bowel tumours than large-bowel tumours. The relationship between the predominant site of tumour development and dosage of DMH was highly significant.Male Wistar rats fed with an all-liquid diet (Vivonex) and treated with 20 mg/kg/wk DMH behaved quite differently both in terms of survival and site of tumour development. These rats survived the full term of the experiment, showed no signs of chemical toxicity, experienced minimal liver damage and developed predominantly large-bowel tumours. The protection afforded by the all-liquid diet against DMH toxicity and small-bowel tumour induction was statistically highly significant.A series of blood tests with special reference to liver function confirmed the highly significant degree of protection against liver damage afforded by the all-liquid diet.Sections of liver from treated rats were examined, and a simple pathological scoring system was devised which showed a highly significant difference in liver histology between standard diet and liquid-diet rats treated with 20 mg/kg/wk DMH.The results strongly suggest an association between severity of liver damage from DMH and the subsequent development of small-bowel tumours. The all-liquid diet protected rats from liver damage and these rats developed significantly fewer small-bowel tumours.

Accession: 039816906

Download citation: RISBibTeXText

PMID: 444411

DOI: 10.1038/bjc.1979.127

Related references

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet. Toxicology Reports 5: 977-987, 2018

Effects of high-fat diet on 1,2-dimethylhydrazine-induced aberrant crypt foci and colorectal tumours in rats. Biomedical Reports 3(3): 289-294, 2015

Effects of diet and ethanol treatment on azoxymethane-induced liver and gastrointestinal neoplasia of male rats. Cancer Letters 107(2): 257-264, 1996

Tumours of the liver and kidney induced in Wistar rats with 4'-fluoro-4-aminodiphenyl. British Journal of Cancer 12(2): 234-241, 1958

Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet. Applied Physiology, Nutrition, and Metabolism 37(6): 1101-1109, 2013

Carcinogen-induced liver tumours of Wistar rats: absence of activatedrasgenes and of N-rasC. Journal of Cancer Research and Clinical Oncology 117(5): 381-384, 1991

N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis: differential pattern of upper gastrointestinal tract tumours in Wistar rats after single or chronic oral doses. Carcinogenesis 14(8): 1561-1567, 1993

Effect of carcinogen 1,2-dimethylhydrazine treatment on fiber types in skeletal muscles of male Wistar rats. Physiological Research 66(5): 845-858, 2017

The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male Wistar rats. Digestive Diseases and Sciences 55(8): 2227-2236, 2010

Carcinogenesis of the colon in Wistar rats induced by 1,2-dimethylhydrazine. Nihon Shokakibyo Gakkai Zasshi 75(12): 1934-1946, 1978

Effects of diet restriction and exercise on adrenal and thyroid hormones and liver and muscle enzymes in aging male wistar rats. FASEB Journal 3(3): A462, 1989

Chemoprevention of colorectal cancer induced by dimethylhydrazine in Wistar rats by tea. Biomedical & Environmental Sciences 14(1-2): 158-159, 2001

Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats. World Journal of Gastroenterology 6(5): 699-703, 2002

Prolonged survival and decrease in intestinal tumours in dimethylhydrazine-treated rats fed a chemically defined diet. British Journal of Cancer 35(4): 491-495, 1977

Temporal relationship between diet-induced steatosis and onset of insulin/leptin resistance in male Wistar rats. Plos One 10(2): E0117008, 2016