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Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion

Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion

Clinical Toxicology 15(4): 437-446

Since there is no widely used method of reducing the severity of massive digoxin intoxication, the capacity of hemoperfusion with coated, activated charcoal to remove digoxin was evaluated in a case of suicidal digoxin ingestion (25 mg). Seven hours after ingestion the digoxin plasma level was equal to 8.9 ng/ml. This was decreased to 4.5 ng/ml after 6 hr hemoperfusion. The amount of digoxin adsorbed by the column represents 4.8% of the absorbed dose. At a blood flow rate of 170 ml/min, the mean digoxin clearance by hemoperfusion was 44.5 +/- 26.9 ml/min. From these results we conclude that charcoal hemoperfusion in acute digoxin intoxication is of little value.

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Accession: 039833358

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PMID: 540492

DOI: 10.3109/15563657908989898

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