Section 40
Chapter 39,861

Does extra-amniotic infection cause preterm labor? Gas-liquid chromatography studies of amniotic fluid in amnionitis, preterm labor, and normal controls

Iams, J.D.; Clapp, D.H.; Contos, D.A.; Whitehurst, R.; Ayers, L.W.; O'Shaughnessy, R.W.

Obstetrics and Gynecology 70(3 Part 1): 365-368


ISSN/ISBN: 0029-7844
PMID: 3627582
Accession: 039860043

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Gas-liquid chromatography (GLC) was used to identify short-chain organic acid byproducts of bacterial metabolism in amniotic fluid from seven normal control patients, six women with overt amnionitis, and six preterm labor patients. Microbiologic culture for aerobic and anaerobic bacteria was also carried out. Positive GLC findings were generally associated with positive cultures, except in five of the preterm labor patients whose GLCs were positive despite negative cultures. The origin of the short-chain organic acids found in these women is unclear; extra-amniotic bacterial growth may explain this finding.

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