+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Does post-tetanic potentiation compensate for low frequency fatigue?



Does post-tetanic potentiation compensate for low frequency fatigue?



Clinical Physiology 9(5): 499-514



The purpose of this study was to examine the effect of post-tetanic potentiation on low frequency fatigue in adult human quadriceps muscle. Sixteen subjects (10 male and six female) performed three 60 s sets of knee extension exercise in order to induce low frequency fatigue (reduction in torque output at 10 and 20 Hz). The potentiating stimulus (a 10 s maximal voluntary contraction) induced a 58% increase in twitch tension (Pt) during the pre-fatigue state. Immediately following the fatiguing exercise, torque (X +/- SE, Nm) at 10 and 20 Hz (submaximal transcutaneous stimulation, 50 microsecond pulses) decreased (P less than 0.05) from 54.8 +/- 5.8 and 94.9 +/- 9.6 to 40.3 +/- 6.1 and 77.0 +/- 11, respectively. Although potentiation at this time increased Pt from 40.9 +/- 4.0 to 54.8 +/- 3.7 (P less than 0.05), torque at 10 and 20 Hz was unaffected. At 60, 120 and 240 min post-contraction, torque at 10 and 20 Hz remained depressed. Following potentiation, which increased twitch tensions to between 64 and 75%, torque at 10 Hz was increased (P less than 0.05) at 60 min (36.3 +/- 4.1 vs. 50.7 +/- 6.2), 120 min (40.8 +/- 6.3 vs. 56.5 +/- 8.9) and 240 min (42.0 +/- 4.7 vs. 57.5 +/- 8.3) of recovery. Similar effects were also noted at 20 Hz. These findings indicate that post-tetanic potentiation can overcome the low frequency fatigue during the post-contraction period and restore torque to pre-exercise levels.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039860789

Download citation: RISBibTeXText

PMID: 2582735

DOI: 10.1111/j.1475-097x.1989.tb01003.x


Related references

Interactive effects of post tetanic potentiation on low frequency fatigue in human muscle. Federation Proceedings 46(3): 640, 1987

Low-frequency fatigue, post-tetanic potentiation and their interaction at different muscle lengths following eccentric exercise. Journal of Experimental Biology 208(Pt 1): 55-63, 2004

Is post-tetanic potentiation, low frequency fatigue (LFF) and pre-contractile depression (PCD) coexistent in intermittent isometric exercises of maximal intensity?. Acta Physiologica Scandinavica 164(2): 127-133, 1998

Human muscle fatigue post tetanic potentiation of low frequency tetani is not related to altered excitation or slowing of relaxation. Journal of Physiology (Cambridge) 394: 141P, 1987

Late switch for post-tetanic potentiation: once again it's Ca2+. Focus on "An increase in calcium influx contributes to post-tetanic potentiation at the rat calyx of Held synapse". Journal of Neurophysiology 96(6): 2840-2841, 2006

Effects of NMDA-receptor antagonist on the frequency potentiation of entorhinal responses during amygdala kindling stimulation and the post-tetanic potentiation. Japanese Journal of Physiology 43(Suppl. 2): S184, 1993

Interrelationships between post tetanic potentiation and fatigue in in vitro stimulated rat diaphragm. Federation Proceedings 46(3): 810, 1987

Simulation of post-tetanic potentiation and fatigue in muscle using a visco-elastic model. Biological Cybernetics 44(2): 129-133, 1982

Frequency and post tetanic potentiation in hippocampal pathways. Zhurnal Vysshei Nervnoi Deyatel'nosti Imeni Ivlova. 1978; 28(3): 650-657, 1978

Early and late post-tetanic potentiation, and post-tetanic block in a monosynaptic reflex pathway. Journal of General Physiology 42(3): 475-488, 1959

Diphasic behavior of post-tetanic potentiation in relation to the frequency of a single stimulus. Bollettino Della Societa Italiana di Biologia Sperimentale 26(9-10): 1417-1419, 1950

Early post-tetanic potentiation and low frequency depression of some group I reflex actions. Journal of General Physiology 41(5): 1005-1018, 1958

Frequency potentiation and post tetanic facilitation of synaptic transmission in the nucleus accumbens in cats. Electroencephalography & Clinical Neurophysiology 52(3): S43, 1981

Post-tetanic potentiation of miniature end-plate potential frequency at neuromuscular junction of the rat soleus muscle. Comparative Biochemistry and Physiology. A Comparative Physiology 87(3): 737-744, 1987

The effect of increased extracellular potassium concentration on the force-frequency curve and post-tetanic potentiation. FASEB Journal 18(4-5): Abst 702 5, 2004