Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice
Crusio, W.E.; Schwegler, H.
Physiology and Behavior 50(1): 259-261
ISSN/ISBN: 0031-9384 PMID: 1946727 DOI: 10.1016/0031-9384(91)90530-2
Newborn male pups of the inbred mouse strain DBA/2J were injected with a buffered solution of L-thyroxine, known to induce a hyperplasia of the intra- and infrapyramidal mossy fiber terminal fields (iip-MF). Because previous studies have shown that the size of the iip-MF correlates positively with both reference memory and working memory in a spatial radial maze task, we expected improved performance on such a task in the treated animals. Such an improvement was in fact found for both reference and working memory. We conclude that the iip-MF are functionally involved in the regulation of spatial learning and memory in mice.