Section 40
Chapter 39,903

Effect of H1- and H2-histamine receptor blockaders on lesions of the gastric mucosa evoked by exogenous histamine in guinea pigs

Karevina, T.G.

Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 5: 43-45


ISSN/ISBN: 0031-2991
PMID: 1981390
Accession: 039902191

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It was demonstrated in experiments on guinea pigs with the use of a histamine model of ulcerogenesis that blocking agents of H1-histamine receptors produced a more marked gastro-protective effect than H2-antagonists. The results of the study confirm the hypothesis that histamine-induced ulceration of the gastric mucosa occurs through the mediation of H1-receptors. H2-histamine receptors play a secondary role in this process.

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