Effect of H1- and H2-histamine receptor blockaders on lesions of the gastric mucosa evoked by exogenous histamine in guinea pigs
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 5: 43-45
ISSN/ISBN: 0031-2991 PMID: 1981390 Accession: 039902191
It was demonstrated in experiments on guinea pigs with the use of a histamine model of ulcerogenesis that blocking agents of H1-histamine receptors produced a more marked gastro-protective effect than H2-antagonists. The results of the study confirm the hypothesis that histamine-induced ulceration of the gastric mucosa occurs through the mediation of H1-receptors. H2-histamine receptors play a secondary role in this process.