Section 40
Chapter 39,906

Effect of acyclovir on the uptake of 131I-labelled 1- (2'fluoro-2'-deoxy-beta-D-arabinofuranosyl) -5-iodouracil in herpes infected cells

Tovell, D.R.; Yacyshyn, H.P.; Misra, H.K.; Knaus, E.E.; Wiebe, L.I.; Samuel, J.; Gill, M.J.; Tyrrell, D.L.

Journal of Medical Virology 22(2): 183-188


ISSN/ISBN: 0146-6615
PMID: 3039053
DOI: 10.1002/jmv.1890220210
Accession: 039905672

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Selective uptake of nucleoside analogues by herpes simplex virus infected cells may serve as the basis for a specific non-invasive diagnostic test for herpes simplex encephalitis. We have examined the effect of acyclovir on the selective uptake of [131I] 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes simplex virus infected primary rabbit kidney cells. Infected cells treated with acyclovir continued to concentrate [131I] 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil for up to 24 h after the addition of the antiviral agent. These results indicated that therapy with acyclovir for as long as 24 h would not prevent the selective trapping of nucleoside analogues. This has important implications for the use of nucleoside analogues in diagnostic brain scans to detect herpes simplex encephalitis.

Effect of acyclovir on the uptake of 131I-labelled 1-(2'fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes infected cells

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