Effect of adrenaline, noradrenaline, dopamine, DOPA and phenylalanine on lipid peroxidation in liver mitochondria membranes

Sergeev, P.V.; Seĭfulla, R.D.; Dunaev, V.G.; Rudnev, I.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 80(12): 25-28


ISSN/ISBN: 0365-9615
PMID: 1225392
Accession: 039906015

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A method of superweak hemifluorescence was applied to the study of the effect of catecholamines on the process of chain peroxidation of lipids in the membranes of hepatic mitochondria in the presence of of Fe2+ ions. It was revealed that catecholamines in the concentrattion range of 10(-6)--10(-4) inhibited this process. On the basis of a mathematical study of the kinetics of the process a calculation was made of the constants of the antioxidative activity of catecholamines which constituted 1.13-10(4) for noradrenaline, 1.04-10(4) for adrenaline, 7.6-10(3) for dophamine, 5-.10(3)M(-1) for DOPA. The antioxidant action of catecholamines was associated with the presence in their molecule of a free phenol group. The mechanism of inhibition consisted in the interaction of catecholamines with the free radicals the leading of the oxidation chain. It is supposed that the antioxidative action of catecholamines could be of significance for the regulation of permeability of the biological membranes.