Effect of aspirin and dexamethasone on intraocular pressure in primary uveitis produced by Herpes simplex virus

Marsettio, M.; Siverio, C.E.; Oh, J.O.

American Journal of Ophthalmology 81(5): 636-641


ISSN/ISBN: 0002-9394
PMID: 179324
Accession: 039909210

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The intracameral injection of New Zealand white male rabbits with type 1 herpes simplex virus produced acute anterior uveitis with biphasic elevation of the intraocular pressure (IOP). The first IOP increase occurred on day 1 and 2 and the second increase on day 8. There was no significant correlation between the IOP changes and multiplication of herpes simplex virus in the uvea and cornea, nor between the IOP changes and histopathologic alteration of the tissue. Aspirin suppressed significantly the first as well as the second IOP elevation, whereas dexamethasone suppressed significantly only the second elevation.