+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of beta blockade on ventricular fibrillation- and ventricular tachycardia-induced circulatory arrest in acute myocardial infarction



Effect of beta blockade on ventricular fibrillation- and ventricular tachycardia-induced circulatory arrest in acute myocardial infarction



American Journal of Cardiology 57(12): 34f-37f



The risk of developing circulatory arrest secondary to ventricular fibrillation or tachycardia in acute myocardial infarction (AMI) is greatly increased in patients with hypokalemia, whether diuretic induced or not. In a retrospective study of 5,877 infarctions during an 8-year period, hypokalemia was more common (22.5%) in diuretic-treated AMI patients than in those not treated with diuretics (12.9%). Thus, hypokalemia should be avoided in diuretic-treated patients with increased risk of myocardial infarction. Circulatory arrest occurred in 13% of hypokalemic patients treated with nonselective beta blockers on admission compared with 26% in those treated with selective beta blockers. No difference was found in normokalemic patients. The mean serum potassium value was 4.07 mM/liter in the patients treated with nonselective beta blockers compared with 4.0 and 4.01 in those treated with selective and no beta blockade, respectively. In a separate study, adrenaline infusion in healthy volunteers produced a decrease not only in serum potassium but also in serum magnesium, although the latter occurred later. Pretreatment with verapamil exaggerated the decrease in serum potassium. When starting beta-blocker treatment in patients at risk of developing AMI, consideration should be given to commencing with a nonselective instead of a selective beta blocker.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039909833

Download citation: RISBibTeXText

PMID: 2871743


Related references

Relation of mortality to failure to prescribe beta blockers acutely in patients with sustained ventricular tachycardia and ventricular fibrillation following acute myocardial infarction (from the VALsartan In Acute myocardial iNfarcTion trial [VALIANT] Registry). American Journal of Cardiology 102(11): 1427-1432, 2008

Prognosis after cardiac arrest due to ventricular tachycardia or ventricular fibrillation associated with acute myocardial infarction (the MILIS Study). Multicenter Investigation of the Limitation of Infarct Size. American Journal of Cardiology 60(10): 755-761, 1987

Effect of flecainide acetate on induced ventricular tachycardia and ventricular fibrillation in dogs with recent myocardial infarction. American Heart Association Monograph (114): III-225, 1985

Determinants of prognosis in symptomatic ventricular tachycardia or ventricular fibrillation late after myocardial infarction. The Dutch Ventricular Tachycardia Study Group of the Interuniversity Cardiology Institute of The Netherlands. Journal of the American College of Cardiology 16(3): 521-530, 1990

Dispersion of repolarization is associated with ventricular fibrillation, but not ventricular tachycardia, during the acute phase of myocardial infarction. Circulation 94(8 SUPPL ): I625, 1996

Utility of the ventricular fibrillation waveform to predict a return of spontaneous circulation and distinguish acute from post myocardial infarction or normal Swine in ventricular fibrillation cardiac arrest. Circulation. Arrhythmia and Electrophysiology 4(3): 337-343, 2011

Induction of ventricular fibrillation during antiarrhythmic drug treatment predicts sudden death in patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation after myocardial infarction. Circulation 90(4 PART 2): I455, 1994

Further observations on ventricular tachycardia as studied by electrical stimulation of the heart. Chronic recurrent ventricular tachycardia and ventricular tachycardia during acute myocardial infarction. Circulation 49(4): 647-653, 1974

Effect of prolonged beta-adrenergic blockade induced by atenolol on left ventricular remodeling after acute myocardial infarction in the rat. Japanese Heart Journal 36(1): 81-89, 1995

Frequency and significance of induced sustained ventricular tachycardia or fibrillation two weeks after acute myocardial infarction. American Journal of Cardiology 56(12): 737-742, 1985

Association of Impaired Thrombolysis In Myocardial Infarction Myocardial Perfusion Grade With Ventricular Tachycardia and Ventricular Fibrillation Following Fibrinolytic Therapy for St-Segment Elevation Myocardial Infarction. Yearbook of Cardiology 2008: 221-223, 2008

Association of impaired thrombolysis in myocardial infarction myocardial perfusion grade with ventricular tachycardia and ventricular fibrillation following fibrinolytic therapy for ST-segment elevation myocardial infarction. Journal of the American College of Cardiology 51(5): 546-551, 2008

Intravenous amiodarone for recurrent polymorphic ventricular tachycardia and ventricular fibrillation related to acute myocardial infarction or coronary artery bypass surgery. Circulation 90(4 PART 2): I545, 1994

Twenty-five year trends (1986-2011) in hospital incidence and case-fatality rates of ventricular tachycardia and ventricular fibrillation complicating acute myocardial infarction. American Heart Journal 208: 1-10, 2018

Induction of ventricular fibrillation, but not of sustained monomorphic ventricular tachycardia predicts sudden death in patients on amiodarone because of ventricular tachyarrhythmias after myocardial infarction. Journal of the American College of Cardiology 0(SPEC ISSUE): 280A, 1994