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Effect of beta-funaltrexamine on retention of passive-avoidance conditioning



Effect of beta-funaltrexamine on retention of passive-avoidance conditioning



Behavioral and Neural Biology 44(3): 499-502



Rats received administration of an opiate antagonist immediately following single-trial passive-avoidance training. Retention of passive-avoidance conditioning was assessed 1 week after training. Compared to noninjected and vehicle-injected control groups, post-training naloxone (2.0 mg/kg) administration significantly increased retention. A comparable facilitation of retention was also observed when animals received post-training administration of beta-funaltrexamine (40 mg/kg). These data provide additional support for mu opiate receptor activity in the regulation of memory processes.

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Accession: 039909989

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PMID: 3002317



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