+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of fragmentation of tetanus immune globulin (human) on neutralization of tetanus toxin



Effect of fragmentation of tetanus immune globulin (human) on neutralization of tetanus toxin



Vox Sanguinis 32(3): 159-164



The effect of fragmentation produced by plasmin digestion of tetanus immune globulin (human) on the neutralization of tetanus toxin was determined. Based on a mouse test, there was a significant reduction in neutralizing potency when fragmentation to 3.5 S material reached or exceeded 20% suggesting a threshold for antibody fragmentation beyond which the resulting decrease in antibody potency would result in serious disease. Because this threshold is not known for man, the use of fragmented globulin for the prevention or treatment of tetanus should be avoided until additional data are available on its neutralizing potency and efficacy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039921274

Download citation: RISBibTeXText

PMID: 855252

DOI: 10.1111/j.1423-0410.1977.tb00620.x


Related references

Adequate dosage of tetanus antitoxin and tetanus-immune human gamma globulin TIG in the treatment of tetanus. Masui. Japanese Journal of Anesthesiology 23(5): 381-387, 1974

Neutralization of tetanus toxin by human monoclonal antibodies directed against tetanus toxin fragment C. Hybridoma 12(6): 699-708, 1993

The potential development of tetanus in wounded patients with AIDS: tetanus toxoid and tetanus immune globulin. Archives of Surgery 121(3): 367, 1986

Therapy of Tetanus with the use of Human Tetanus Antitoxin in the Form of Gamma Globulin (Tetanus Hyperimmune Globulin). Munchener Medizinische Wochenschrift 107: 854-857, 1965

Current Status of Tetanus Control. Importance of Human Tetanus-Immune Globulin. JAMA 188: 625-627, 1964

Tetanus toxoid boosters and human immune globulin for tetanus prophylaxis. New York State Journal of Medicine 72(10): 1131-1135, 1972

Isolation of fragments corresponding to domains a b c of the tetanus toxin molecule and preparation of human anti tetanus monoclonal antibodies with high neutralizing activity for study of structure function of tetanus toxin. Abstracts of Papers American Chemical Society 200(1-2): AGFD 53, 1990

Fatal tetanus after prophylaxis with human tetanus immune globulin. JAMA 207(8): 1519, 1969

Immune globulin against tetanus, a tetanus antitoxin of human origin. Svenska Lakartidningen 60: 1483-1492, 1963

Characteristics of toxin-neutralization by anti-tetanus human monoclonal antibodies directed against the three functional domains [A], [B] and [C] of the tetanus toxin molecule and a reliable method for evaluating the protective effects of monoclonal antibodies. European Journal of Epidemiology 8(1): 1-8, 1992

Characteristics of Toxin-Neutralization by Anti-Tetanus Human Monoclonal Antibodies Directed against the Three Functional Domains [A], [B] and [C] of the Tetanus Toxin Molecule and a Reliable Method for Evaluating the Protective Effects of Monoclonal Antibodies. European Journal of Epidemiology 8(1): 1-8, 1992

Studies of tetanus toxin and antitoxin in human sera. II. Comparison of hemagglutination and mouse neutralization tests for determining circulating human tetanus antitoxin. Medical Technicians Bulletin 8(4): 149-154, 1957

Tetanus immune globulin (human) in prophylaxis against tetanus. Journal of Pediatrics 67(4): 643-646, 1965

Neutralization of bacterial exo toxin tetanus toxin by channel catfish ictalurus punctatus immuno globulin m antibody. Federation Proceedings 41(3): ABSTRACT 3265, 1982

Simultaneous prophylaxis against tetanus using tetanus vaccine and human anti-tetanus globulin. Z Immunitats Forsch Allergie Klin Immunol 132(3): 261-275, 1967