Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells

Ng, T.B.; Wong, C.M.; Yeung, H.W.

Journal of Ethnopharmacology 16(2-3): 191-199


ISSN/ISBN: 0378-8741
PMID: 3018381
DOI: 10.1016/0378-8741(86)90089-9
Accession: 039921860

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Ginsenosides Rb2, Rc and Rg1 suppressed corticotropin-induced, dibutyryl cyclic AMP-induced and epinephrine-induced lipolysis with the relative potencies Rb2 greater than Rc greater than Rg1. The inhibition of corticotropin-induced lipolysis by ginsenoside Rg1 could not be overcome by increasing the dose of the lipolytic hormone while that of ginsenosides Rc and Rb2 was nearly abolished by corticotropin at a dose of 40 nM which by itself produced maximal lipolysis. Dibutyryl cyclic AMP-stimulated lipolysis was also inhibited. Only ginsenoside Rb2 suppressed glucagon-induced lipolysis. All three ginsenosides did not inhibit basal lipolysis or basal incorporation of D-[3-3H]glucose into lipids. Insulin-stimulated lipogenesis was diminished by ginsenosides Rg1 and Rc but not by ginsenoside Rb2.