+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of glucocorticoid on lung tissue and bronchus-associated lymphoid tissue of experimental granulomatous lung

Effect of glucocorticoid on lung tissue and bronchus-associated lymphoid tissue of experimental granulomatous lung

Kekkaku 64(6): 387-399

The effect of glucocorticoid on the immunological response in the delayed type hypersensitivity reaction of granulomatous disorders was investigated in order to elucidate the mechanism of glucocorticoid on the suppressive course of the reaction. Experimental pulmonary granuloma model in rats was induced by an intravenous injection of heat killed BCG, and the effects of methylprednisolone (MPSL) on the granulomatous lung tissue, bronchus associated lymphoid tissue (BALT) and the population of cells from bronchoalveolar lavage fluid (BALF) and peripheral blood were examined by the cytological and immunohistochemical methods. The pulmonary granulomatous reaction was reduced effectively by the administration of MPSL. A remarkable reduction of the number of Ia antigen positive alveolar macrophages (Ia+ A.M phi) and T lymphocytes in the granulomatous lung tissue and BALF was observed. T helper cells to non-helper cells (TH/TNH) ratio in BALF decreased remarkably. Furthermore, a reduction of Ia antigen positive macrophages (Ia+ M phi) and T cells was noted in the parafollicular area of BALT. These findings suggest that glucocorticoid may suppress the immunological activity of M phi and T cell through its inhibitory effect on the differentiation of Ia+ M phi and activated T cells, which result in the diminishment of pulmonary granulomatous reaction through the disorder of M phi - T cell interaction. On the other hand, lymphocytopenia with decreased TH/TNH ratios in peripheral blood was observed simultaneously with the reduction of the pulmonary granulomatous reaction. Thus, the mechanism of reduced pulmonary granulomatous reaction after MPSL administration may be not only due to local immunosuppression, but also to impaired systemic immune response. In addition, the disappearance of the germinal center and the reduction of surface IgM-positive cells in the follicular area of BALT occurred with the reduction of pulmonary granulomatous reaction. These results suggest that glucocorticoid also suppress the humoral immune responses in BALT during the course of delayed type hypersensitivity reaction.

(PDF emailed within 1 workday: $29.90)

Accession: 039921982

Download citation: RISBibTeXText

PMID: 2796110

Related references

Analysis of delayed type hypersensitivity reaction of the experimental granulomatous lung--changes in T-cell and B-cell subpopulations in the bronchus-associated lymphoid tissue. Kekkaku 63(4): 215-226, 1988

T cell localization in gut associated lymphoid tissue bronchus associated lymphoid tissue and lung parenchyma in rabbit models of hypersensitivity pneumonitis. Federation Proceedings 45(4): 995, 1986

Mucosa-associated lymphoid tissue lymphoma of the esophagus coexistent with bronchus-associated lymphoid tissue lymphoma of the lung. Yonsei Medical Journal 46(4): 562-566, 2005

Subpopulations of non-lymphoid cells in bronchus associated lymphoid tissue and lung of the mouse. Advances in Experimental Medicine and Biology 237: 607-613, 1988

Bronchus-associated lymphoid tissue hyperplasia of the lung. Ajr. American Journal of Roentgenology 168(4): 1044-1044, 1997

Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung. Frontiers in Immunology 7: 258-258, 2016

Depletion of bronchus-associated lymphoid tissue associated with lung allograft rejection. American Journal of Pathology 132(1): 6-11, 1988

Low CD4/CD8 Ratio in Bronchus-Associated Lymphoid Tissue Is Associated with Lung Allograft Rejection. Journal of Transplantation 2012: 928081-928081, 2012

The significance of bronchus-associated lymphoid tissue in human lung transplantation. Transplantation (Baltimore) 67(3): 381-385, Feb 15, 1999

Importance of bronchus-associated lymphoid tissue and major histocompatibility complex class I and class II antigen expression on bronchial epithelium in acute lung allograft rejection and lung infection in rats. Transplantation Proceedings 26(4): 1856-1858, 1994

Bronchus-associated lymphoid tissue (BALT) in human fetal and infant lung. Journal of Pathology 169(2): 229-234, 1993

Autoreactive bronchus-associated lymphoid tissue in interstitial lung disease: friend or foe?. American Journal of Respiratory Cell and Molecular Biology 48(4): 397-398, 2013

Autoreactive T and B cells induce the development of bronchus-associated lymphoid tissue in the lung. American Journal of Respiratory Cell and Molecular Biology 48(4): 406-414, 2013

Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. American Journal of Pathology 184(5): 1577-1592, 2014

Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology 68(1): 1-8, 2000