Effect of histamine H1- and H2-receptor blockade on canine gastric acid secretion

Barbezat, G.O.; Bowey, F.S.; Kaplan, E.R.; Hickman, R.

American Journal of Digestive Diseases 23(3): 222-224


ISSN/ISBN: 0002-9211
PMID: 665610
DOI: 10.1007/bf01072321
Accession: 039923607

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In dogs with gastric fistulae and Heidenhain pouches, inhibition of histamine-stimulated gastric acid secretion by the histamine H2-receptor antagonist metiamide is not increased by the addition of a histamine H1-receptor antagonist (mepyramine maleate). Under the conditions of this study there is no evidence for the presence of histamine H1-receptor sites on the gastric parietal cell.