Effect of in vivo thyroid hormones and IGL on protein synthesis in the mitochondria of thyroidectomized animals

Rachev, R.R.; Dimitrov, M.I.; Stanoeva, N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 86(8): 167-170


ISSN/ISBN: 0365-9615
PMID: 687810
Accession: 039925317

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The authors studied the effect of triiodothyronine (T3) and IGL on the intensity of L-14C-tyrosine incorporation, and on the rate of protein of synthesis in the liver mitochondria of thyroidectomized rats, as well as on radioactivity of the liver amino acid poll. It was found that the intensity of L-14C-tyrosins incorporation into the protein of the liver mitochondria in thyroidectomized animals and the rate of protein synthesis in them was half that in sham-operated animals. T3 or IGL administration to thyroidectomized rats normalized protein synthesis in the liver mitochondria. According to all the biochemical indices studied the IGL effect was analogous to that of triiodothyronine. The absence of thyroid hormones in the organism of thyroidectomized animals, or T3 or IGL administration had no effect on the radioactivity of the free tyrosine pool in the liver tissue.