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Effect of maternal protein deprivation on the development of neonatal intestinal function in rats

Ferdinandus, L.D.; Fitzgerald, J.F.

Pediatric Research 11(7): 804-808

1977


ISSN/ISBN: 0031-3998
PMID: 406591
DOI: 10.1203/00006450-197707000-00005
Accession: 039930008

The developmental pattern of in vitro intracellular accumulation (IA) was studied in the small intestine of the offspring of females fed a 27% protein diet (normal) (NPD animals) and the offspring of females fed an 8% protein diet (low) (LPD animals). At 2 days of age, the IA of L-leucine (Leu) and D-galactose (Gal) was significantly reduced in the intestines of the LPD animals as compared to the NPD animals at initial velocities (75% and 81%) and under steady state conditions (82% and 84%). The IA of both compounds in the intestines of the LPD animals increased relative to the NPD animals until at weaning the IA of Leu and Gal under steady state conditions was significantly greater in the LPD animals (139% and 133%). After weaning, the IA of Leu was statistically increased (137%) and the IA of Gal was the same in the LPD animals as compared to the NPD animals at initial velocities. The variations in the developmental patterns of the IA of Leu and Gal in the intestines of LPD animals as compared to NPD animals appear to be related to animal age, which may reflect an improved caloric intake at weaning.

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