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Effect of sea nettle (Chrysaora quinquecirrha) venom on isolated rat aorta

Effect of sea nettle (Chrysaora quinquecirrha) venom on isolated rat aorta

Toxicon 26(12): 1209-1212

The venom from sea nettle (Chrysaora quinquecirrha) (1-10 micrograms/ml) produced an irreversible contraction of the isolated rat aortic ring that was slow in onset, increased with time, and reached maximum in about 10-20 min. The contraction was not inhibited by pretreatment with phenoxybenzamine, atropine, indomethacin, tetrodotoxin, ouabain, low Na+ or Na+-free medium, however, it was markedly decreased by the Ca2+ channel blockers, nifedipine and verapamil. In Ca2+-free medium, no increase in tension was produced by the venom. It is concluded that sea nettle venom causes a contraction of the rat aortic ring by increasing Ca2+ influx through the voltage-dependent Ca2+ channels.

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Accession: 039939742

Download citation: RISBibTeXText

PMID: 2907190

DOI: 10.1016/0041-0101(88)90306-6

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