+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of total parenteral nutrition on biliary lipids in neonates



Effect of total parenteral nutrition on biliary lipids in neonates



Canadian Journal of Surgery. Journal Canadien de Chirurgie 29(4): 289-291



To study the effect of total parenteral nutrition (TPN) on biliary lipids in critically ill neonates, biliary lipid concentrations were determined in 13 neonates before starting TPN, in 8 receiving TPN for up to 2 weeks and in 9 receiving TPN for up to 8 weeks. Bile was very dilute in the 13 neonates not receiving TPN owing to a low concentration of bile acids. In many the bile-acid concentration was below the critical micellar concentration, thus cholesterol in bile was not dissolved. The neonates receiving TPN for up to 2 weeks showed a marked increase in bile-acid content and had levels above the critical micellar concentration. This apparently beneficial effect of TPN disappeared after 2 weeks and neonates who received TPN for 3 to 8 weeks again had bile-acid levels below the critical micellar concentration. Three conclusions may be drawn from this study: (a) in the fasting state before TPN is begun, the cholesterol content of bile relative to phospholipid and bile acids increased in linear fashion during the fasting period; (b) short-term TPN of up to 2 weeks' duration was associated with an increased bile-acid content to levels at which cholesterol could be dissolved; (c) neonates on long-term TPN and no oral intake secrete extremely dilute bile with an insufficient concentration of bile-acid molecules to form micelles to dissolve cholesterol. This finding may explain some of the adverse hepatobiliary changes associated with long-term administration of TPN.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039946957

Download citation: RISBibTeXText

PMID: 3089573


Related references

Effect of total parenteral nutrition with intravenous fat on lipids and high density lipoprotein heterogeneity in neonates. Jpen. Journal of Parenteral and Enteral Nutrition 13(5): 490-500, 1989

Bolus intravenous infusion of amino acids or lipids does not stimulate gallbladder contraction in neonates on total parenteral nutrition. Journal of Pediatric Surgery 33(6): 817-820, 1998

Bolus Intravenous Infusion of Amino Acids or Lipids Does Not Stimulate Gallbladder Contraction in Neonates on Total Parenteral Nutrition. Nutrition in Clinical Practice 14(3): 147-148, 1999

Internal biliary drainage, parenteral nutrition, and variation in the total parenteral nutrition feeding solutions: influence on the healing of colon anastomosis in jaundiced rats. Jpen. Journal of Parenteral and Enteral Nutrition 14(6): 629-633, 1990

Comparison between Total Parenteral Nutrition Vs. Partial Parenteral Nutrition on Serum Lipids Among Chronic Ventilator Dependent Patients; A Multi Center Study. Tanaffos 15(1): 31-36, 2016

Effect of phosphorus in total parenteral nutrition infusates in premature neonates. Pediatric Research 20(4 Part 2): 420A, 1986

Serum lipids in total parenteral nutrition (TPN): effect of fat. Journal of Surgical Research 24(6): 527-531, 1978

The effect of total parenteral nutrition-induced cholestasis on theophylline clearance in neonates. Therapeutic Drug Monitoring 10(4): 390-394, 1988

Effect of phosphorus intake in total parenteral nutrition infusates in premature neonates. Journal of pediatrics 110(4): 586-590, 1987

Effect of total parenteral nutrition induced cholestasis on theophylline clearance in neonates. Drug Intelligence & Clinical Pharmacy 21(7-8 Part 1 ABSTR): 3A, 1987

The effect of intravenous fat and total parenteral nutrition on biliary physiology. Jpen. Journal of Parenteral and Enteral Nutrition 8(3): 263-268, 1984

Lipids for parenteral nutrition in neonates. Current Opinion in Clinical Nutrition and Metabolic Care 14(2): 145-150, 2011

Effect of total parenteral nutrition tpn on blood lipids and liver enzymes. FASEB Journal 4(3): A519, 1990

Glutamine prevents the biliary lithogenic effect of total parenteral nutrition in rats. Journal of Surgical Research 58(5): 491-495, 1995

Effect of continuous and discontinuous intravenous or intragastric total parenteral nutrition in rats on serum lipids, liver lipids and liver lipogenic rates. Journal of Nutrition 116(5): 733-741, 1986