Section 40
Chapter 39,949

Effect of variation in compaction force on properties of six direct compression tablet formulations

Khan, K.A.; Rhodes, C.T.

Journal of Pharmaceutical Sciences 65(12): 1835-1837


ISSN/ISBN: 0022-3549
PMID: 1032674
DOI: 10.1002/jps.2600651235
Accession: 039948301

The effect of variation in compaction force on six direct compression tablet matrixes was investigated. An instrumented tablet press allowed direct measurement of applied and ejection forces. Hardness, apparent tablet density, and disintegration times also were determined. The disintegration time of spray-dried lactose tablets was essentially independent of compaction force. However, in the other systems investigated, the properties studied showed varying types of dependence on compaction pressure. A direct compression formula was developed and exhibits a decrease in disintegration time as compaction force is increased.

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