Section 40
Chapter 39,949

Effect of various antibiotics on Listeria monocytogenes multiplying in L 929 cells

Nichterlein, T.; Hof, H.

Infection 19(Suppl 4): S234-S238


ISSN/ISBN: 0300-8126
PMID: 1908835
DOI: 10.1007/bf01644040
Accession: 039948359

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Various antibiotics were evaluated as to their effect on Listeria monocytogenes SLCC 4013 multiplying within L 929 mouse fibroblast cells. Antibiotics were employed in concentrations above the MIC value. However, there was no measurable effect of some drugs on intracellular listeriae (azlocillin, mezlocillin, cephalothin, ciprofloxacin, chloramphenicol). With other drugs an inhibition of intracellular growth was observed (penicillin, ampicillin, rifampicin, rifapentine, erythromycin, doxycycline, co-trimoxazole, coumermycin). Notably, with none of the antibiotics a complete eradication of the listeriae was achieved. There is a good correlation of these results with animal experiments. Therefore, the cell culture system might be useful for the screening of new antibiotics.

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