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Effects of bezafibrate on lipoprotein lipids and apolipoproteins B and A1 in patients with primary hypercholesterolemia

Effects of bezafibrate on lipoprotein lipids and apolipoproteins B and A1 in patients with primary hypercholesterolemia

La Clinica Terapeutica 122(1): 17-23

ISSN/ISBN: 0009-9074

PMID: 2973892

Thirty-eight patients with primary hypercholesterolemia have been treated with bezafibrate 200 mg t.i.d. after a period of dietary stabilization. After one month of bezafibrate treatment in type IIa patients, serum cholesterol fell on average by 20%, serum triglycerides by 25% apoB by 24% and apoA1 showed a slight but not significant increase. VLDL triglycerides decreased by 40%, LDL cholesterol by 24% and HDL cholesterol increased (7%) owing to the increase of the HDL3 cholesterol subfraction. In type IIb patients serum cholesterol decreased by 19%, serum triglycerides by 25%, and apoB by 29% while apoA1 increased by 19%, VLDL triglycerides decreased on average by 65% and LDL cholesterol by 20%. HDL cholesterol increased by 25% due to the increase of HDL2-cholesterol concentration while HDL3 cholesterol showed only a minor and non-significant increase. After 4 months the serum lipoprotein pattern was unchanged compared to that observed after 1 month of treatment. Changes in VLDL triglycerides, HDL cholesterol and apoA1 were greater in type IIb patients while those of LDL cholesterol and apoB were similar. Atherogenic indexes significantly decreased in both groups of patients. Modifications of lipoprotein patterns induced by bezafibrate are consistent with a reduction of cardiovascular risk in patients with type IIa and type IIb hyperlipoproteinemia.

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Accession: 039960512

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