+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens



Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens



Psychopharmacologia 47(2): 195-198



Ergometrine (8 mg/kg) injected intraperitoneally into normal rats had little effect on locomotor activity. In contrast, rats with selective 6-hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens showed a strong stimulation of locomotor activity following injection of this dose or ergometrine. The dopamine analogue 2-amino-6-7-dihydroxy-1, 2, 3, 4-tetrahydronaphthalene (ADTN) (150 mug), caused strong and long lasting stimulation of locomotor activity when injected intracerebroventricularly into rats. The ADTN response was markedly reduced in rats with bilateral electrolytic lesions of the nucleus accumbens, but unchanged in rats with bilateral electrolytic lesions of the caudate nucleus. At a lower dose level (50 mug) ADTN, injected intracerebroventricularly, had little effect on the locomotor activity of normal or sham-operated rats. This dose of ADTN was, however, effective in causing locomotor stimulation of rats with bilateral 6-hydroxydopamine-induced lesions of the nucleus accumbens. These results support the view that the dopamine receptors in the nucleus accumbens are involved in the actions of locomotor stimulant drugs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039966190

Download citation: RISBibTeXText

PMID: 1273217

DOI: 10.1007/bf00735821


Related references

Comparative effects of infusions of 6 hydroxydopamine into nucleus accumbens and anterolateral hypothalamus induced by 6 hydroxydopamine on the response to dopamine agonists body weight locomotor activity and measures of exploration in the rat. Neuropharmacology 24(1): 25-32, 1985

Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: comparisons to other psychomotor stimulants. Psychopharmacology 82(1-2): 83-88, 1984

Aporphines. 16. Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens. European Journal of Pharmacology 35(1): 85-92, 1976

Effects of age on dopamine release in the nucleus accumbens and amphetamine-induced locomotor activity in rats. Neuroscience Letters. 200(1): 61-64, 1995

Effects of amphetamine and apomorphine on locomotor activity after 6-OHDA and electrolytic lesions of the nucleus accumbens septi. Pharmacology Biochemistry and Behavior 19(1): 137-143, 1983

Mu opioid agonist augments locomotor activity after bilateral 6 hydroxydopamine lesions in the nucleus accumbens without involving receptor upregulation. Society for Neuroscience Abstracts 16(2): 907, 1990

Toluene-induced locomotor activity is blocked by 6-hydroxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268. Neuropsychopharmacology 28(8): 1440-1447, 2003

Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. Journal of Comparative and Physiological Psychology 92(5): 917-927, 1978

Differential and asymmetrical behavioral effects of electrolytic or 6-hydroxydopamine lesions in the nucleus accumbens. Brain Research 401(1): 147-151, 1987

Electrolytic lesions of the nucleus accumbens enhance locomotor sensitization to nicotine in rats. Behavioral Neuroscience 120(3): 600-611, 2006

Electrolytic lesions on the nucleus accumbens in rats enhance locomotor sensitization to 04 MG/KG nicotine. Society for Neuroscience Abstracts 22(1-3): 474, 1996

The effects of an electrolytic lesion of the dorsomedial shell of the nucleus accumbens on cocaine-induced locomotor activity and sensitization. Society for Neuroscience Abstracts 27(1): 1183, 2001

Effects of D3/D2 dopamine receptor agonist 7-OH-DPAT on locomotor activity and extracellular dopamine and 5-HT release in the nucleus accumbens. Journal of Neurochemistry 70(Suppl. 2): S36, 1998

Effects of amphetamine and apo morphine on loco motor activity after 6 hydroxy dopamine and electrolytic lesions of the nucleus accumbens septi. Pharmacology Biochemistry & Behavior 19(1): 137-144, 1983

Electrolytic lesions of the nucleus accumbens in rats which abolish the PREE enhance the locomotor response to amphetamine. Experimental Brain Research 86(2): 333-340, 1991