+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Efficacy of thrombolytic therapy for occlusion of long-term catheters

Efficacy of thrombolytic therapy for occlusion of long-term catheters

Jpen. Journal of Parenteral and Enteral Nutrition 14(3): 312-314

Nineteen ambulatory outpatients requiring a tunneled central venous access device with catheter occlusion were studied. Mean catheter life was 7.9 +/- 8.2 months (range, from 1-36 months) at the time of the occlusion. Urokinase (5000 units/ml) was injected in sufficient amount to fill the internal volume of the catheter and allowed to stay for 5 to 10 min before attempting to aspirate. Repeated aspiration attempts were performed every 5 to 10 min for a maximum of 30 to 60 min or patency. In the event catheter patency was not restored, the thrombolytic solution was aspirated from the catheter and a maximum of two additional trials were instituted. Results included clearance of four out of 15 withdrawal occlusions (27%) and two out of four resistance to infusion occlusions (50%). Overall, successful catheter clearance occurred in six out of 19 occlusions (32%). The efficacy rate of thrombolytic therapy for successfully clearing occluded catheters at our institution using conventional low-dose thrombolytic therapy is markedly lower than previously reported rates of 57 to 100%. The reasons for this discrepancy may reflect differences in dosage of thrombolytic agent, method of administration, frequency of monitoring of catheter patency, and catheter life.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039990819

Download citation: RISBibTeXText

PMID: 2112649

DOI: 10.1177/0148607190014003312

Related references

Thrombolytic therapy for occlusion of long term catheters. Journal of the American College of Nutrition 8(5): 428, 1989

Therapy for thrombotic occlusion of long-term intravenous alimentation catheters. Jpen. Journal of Parenteral and Enteral Nutrition 4(4): 387-390, 1980

Long-term follow-up of patients after intraarterial thrombolytic therapy of acute vertebrobasilar artery occlusion. Cerebrovascular Diseases 12(3): 214-219, 2001

Long-term efficacy of acute thrombolytic therapy for myocardial infarction. Internal Medicine 33(7): 387-395, 1994

Long-term efficacy of pre-hospital thrombolytic therapy in acute myocardial infarction. European Heart Journal 15(ABSTR Suppl. ): 595, 1994

Short-term continuous infusion thrombolytic therapy for occluded central nervous venous dialysis catheters. American Journal of Managed Care 3(2): 261-264, 1997

Efficacy of continuous thrombolytic therapy for portal vein occlusion after hepatobiliary pancreatic surgery. European Radiology 17(8): 2189-2191, 2007

Management of occlusion and thrombosis associated with long-term indwelling central venous catheters. Lancet 374(9684): 159-169, 2009

Approach to thrombotic occlusion related to long-term catheters of hemodialysis patients: a narrative review. Jornal Brasileiro de Nefrologia 37(2): 221-227, 2017

Short-term cognitive-behavioral therapy for binge eating disorder: long-term efficacy and predictors of long-term treatment success. Behaviour Research and Therapy 58: 36-42, 2014

Incidence of residual thrombi following successful thrombolytic therapy in acute myocardial infarct and their significance for the rate of early re-occlusion. A report of a multicenter dose-finding study for thrombolytic therapy with urokinase preactivated natural prourokinase (TCL 598). Zeitschrift für Kardiologie 79(4): 279-285, 1990

Long term follow up after thrombolytic therapy. European Heart Journal 8(ABSTR Suppl. 2): 48, 1987

Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children. Cochrane Database of Systematic Reviews 2015(11): Cd010996, 2015

Superiority of warfarin over asa long term after thrombolytic therapy. Clinical Research 36(3): 315A, 1988

Comparative analysis of long-term mortality after thrombolytic therapy. American Journal of Cardiology 68(16): 38e-44e, 1991