+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Enzymatic determination of serum neuron-specific enolase in small cell lung cancers. Utility of the serum neuron-specific enolase/serum nonneuronal enolase ratio



Enzymatic determination of serum neuron-specific enolase in small cell lung cancers. Utility of the serum neuron-specific enolase/serum nonneuronal enolase ratio



Chest 93(6): 1225-1233



Increasing interest is shown in the determination of the serum neuron-specific enolase for the diagnosis and the follow-up studies of small cell lung cancers. We report results obtained by an enzymatic procedure that permits the simultaneous determination of the neuron and nonneuron-specific enolase and the calculation of the ratio of these two components. The utility of this ratio which characterizes elevations of the serum neuron-specific enolase from a poor or rich source of this component was tested in 38 patients with small cell lung carcinoma and in 57 subjects suffering from other bronchogenic cancers. The control group consisted of 37 blood donors and 56 patients with respiratory disease. For the diagnosis, the sensitivity and the specificity of the enzymatically determined neuron-specific enolase compared well with published results obtained by radioimmunoassay and enzymoimmunoassay. The use of the ratio clearly increases the specificity of the test, since only 5.3 percent of false positive results are found when bronchogenic tumors other than small cell carcinoma are studied. The sensitivity was 76 and 100 percent in diagnosis of limited and extensive forms, respectively. The use of this ratio in the follow-up of the patients and for the determinations in hemolyzed samples is set out.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040029949

Download citation: RISBibTeXText

PMID: 2836136


Related references

Enzymatic Determination of Serum Neuron-specific Enolase in Small Cell Lung Cancers. Chest Journal 93(6): 1225-1233, 1988

High neuron specific enolase levels in bronchoalveolar lavage fluid of patients with lung carcinoma: diagnostic value, relation to serum neuron specific enolase, and staging. Cancer 77(10): 2039-2043, 1996

Serum neuron-specific/nonneuronal enolase ratio in the diagnosis of neuroblastomas. Cancer 62(12): 2546-2553, 1988

Potential utility of serum neuron-specific enolase levels in small cell carcinoma of the lung. Cancer Research 44(11): 5409-5414, 1984

Immuno histochemical demonstration of neuron specific enolase and s 100 protein in neuro endocrine tumors correlation with serum and tissue levels of neuron specific enolase. Laboratory Investigation 48(1): 79A, 1983

Immunohistochemical localization of neuron-specific enolase in gastroenteropancreatic neuroendocrine tumors. Correlation with tissue and serum levels of neuron-specific enolase. Cancer 54(7): 1364-1369, 1984

Neuron-specific enolase in small-cell carcinoma of the lung: the value of combined immunocytochemistry and serum determination. Anticancer Research 9(6): 1717-1720, 1989

Tl/ 67 Ga Uptake Ratio in Small Cell Carcinoma of the Lung: With Special Reference to Serum Neuron-Specific Enolase and Prognosis. Oncology 44(4): 228-231, 1987

Serum neuron-specific enolase in small cell bronchial cancers. Revue de Pneumologie Clinique 46(4): 161-165, 1990

201Tl/67Ga uptake ratio in small cell carcinoma of the lung: with special reference to serum neuron-specific enolase and prognosis. Oncology 44(4): 228-231, 1987

Thallium 201 gallium 67 uptake ratio in small cell carcinoma of the lung with special reference to serum neuron specific enolase and prognosis. Oncology 44(4): 228-231, 1987

Serum neuron specific enolase in small cell lung cancer. Clinical Research: 855a, 1983

Serum neuron specific enolase s nse is higly specific for small cell lung cancer sclc. Chest 92(2 Suppl.): 88S, 1987

Serum neuron-specific enolase as a marker of lung cancers. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 12(1): 139-143, 1985

The changes in serum neuron-specific enolase in patients with small cell lung cancer. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(11): 3046-3049, 1987