+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Epidermal Langerhans' cells and dermal dendritic cells in human fetal and neonatal skin: an immunohistochemical study

Epidermal Langerhans' cells and dermal dendritic cells in human fetal and neonatal skin: an immunohistochemical study

Pediatric Dermatology 4(1): 11-17

The dendritic cells in skin biopsies from 36 fetuses (from 16 weeks' gestational age on) and neonatal infants of different ages were investigated using a number of markers for various cells of the immune system and immunohistochemistry. Epidermal Langerhans' cells were found in all cases in a predominantly basal localization. The number of OKT6-positive Langerhans' cells and the development of their dendritic processes gradually increased with age. Dermal dendritic cells were present as well. Both HLA-DR-positive and Leu-10-positive dermal dendritic cells were found in the superficial and deep dermis, often in a perivascular distribution. The OKT6-positive dermal dendritic cells were few in number and occurred only in the upper dermis.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040038260

Download citation: RISBibTeXText

PMID: 3588433

Related references

Immunohistochemical and immunoelectron microscopic study of epidermal langerhans cells and dermal dendritic cells in murine fetal and neonatal skin. Thivolet, J And D Schmitt (Ed ) Colloque Inserm (Institut National De La Sante Et De La Recherche Medicale), Vol 172 La Cellule De Langerhans; (Inserm (National Institute Of Health And Medical Research) Colloquium), Vol 172 The Langerhans Cell; Second Workshop, Lyon, France, April 21-22, Xxv+492p Les Editions Inserm: Paris, France; John Libbey And Co Ltd : London, England, Uk Illus Paper 33-40, 1988

Immunohistochemical study of epidermal Langerhans cells and dermal dendritic cells in benign and malignant skin lesions characterized by a dermal lymphoid infiltrate consisting either of B-cells or T-cells. Virchows Archiv. A Pathological Anatomy and Histopathology 411(4): 337-343, 1987

Epidermal Langerhans cells, dermal dendritic cells, and keratinocytes in viral lesions of skin and mucous membranes: an immunohistochemical study. Archives of Dermatological Research 280(4): 220-227, 1988

Application of Microneedles to Skin Induces Activation of Epidermal Langerhans Cells and Dermal Dendritic Cells in Mice. Biological and Pharmaceutical Bulletin 39(8): 1309-1318, 2016

Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 29(3): 497-510, 2008

Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. Plos Pathogens 11(4): E1004812, 2015

Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. Journal of Immunology 168(9): 4361-4371, 2002

Effects of solar ultraviolet radiation on engineered human skin equivalent containing both Langerhans cells and dermal dendritic cells. Tissue Engineering 13(11): 2667-2679, 2007

Brugia malayi infective larvae fail to activate Langerhans cells and dermal dendritic cells in human skin. Parasite Immunology 37(2): 79-91, 2015

The abundant expression of FC-epsilon-RI in lesional atopic dermatitis skin is due to upregulation of FC-epsilon-RI on epidermal Langerhans cells and to accumulation of FC-epsilon-RI-bearing dermal dendritic cells. Journal of Investigative Dermatology 108(4): 610, 1997

Characterization of nonhuman primate epidermal and dermal dendritic cells with monoclonal antibodies. A study of Langerhans cells and indeterminate cells in the rhesus monkey. Laboratory Investigation; A Journal of Technical Methods and Pathology 56(3): 313-320, 1987

Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. Journal of Leukocyte Biology 84(1): 143-151, 2008

Epitopes for CD1a, CD1b, and CD1c antigens are differentially mapped on Langerhans cells, dermal dendritic cells, keratinocytes, and basement membrane zone in human skin. Journal of the American Academy of Dermatology 27(3): 419-426, 1992

Langerhans cells and dermal dendritic cells capture protein antigens in the skin: possible targets for vaccination through the skin. Immunobiology 215(9-10): 770-779, 2010

Langerhans cells, dermal dendritic cells and monocyte-derived dendritic cells are distinct subsets of myeloid dendritic cells defined by diverse functional properties. Archives of Dermatological Research 295(8-9): 342, 2004