Erythropoietin and erythropoiesis inhibitor in neonatal hypoxia and normal conditions

Gudim, V.I.; Mikhel', A.; Sigalla, P.; Ivanova, V.S.; Gross, I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 86(8): 156-158


ISSN/ISBN: 0365-9615
PMID: 687808
Accession: 040046881

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In 22 healthy newborns and in 31 newborns with transposition of the major arterial vessels (TMAV) erythropoietin and erythropoiesis inhibitor was studied on a model of polycythemic mice. Erythropoietin was not detected, whereas erythropoiesis inhibitor was revealed in the plasma and urine of 5--7-day-old healthy newborns. The newborns with TMAV displayed a rise of erythropoietin level up to the 14th day and its reduction during the period of from 14th to the 56th days. Erythropoiesis inhibitor was also found in the urine concentrates of the newborn with TMAV during the period of 3--4 weeks. The role of erythropoiesis inhibitor as a physiological regulator appearing in the blood of healthy and hypoxic newborns to normalize the erythropoiesis in the course of the initial weeks after birth is discussed.