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Estimation of a common odds ratio in case-control studies of familial aggregation


Estimation of a common odds ratio in case-control studies of familial aggregation



Biometrics 44(2): 369-378



ISSN/ISBN: 0006-341X

PMID: 3390505

DOI: 10.2307/2531851

A new estimator of a common odds ratio is proposed for case-control studies of familial aggregation. The proposed estimator is a modification to the usual Mantel-Haenszel estimator that relies on an empirical adjustment for the within-family clustering which is typical of such designs. A simulation study shows that the estimator tends to have smaller mean squared error than the unmodified Mantel-Haenszel estimator under conditions likely to arise in practice. The construction of confidence intervals is also discussed.

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Accession: 040051641

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Related references

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