+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma estrogen and progesterone levels

Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma estrogen and progesterone levels

Cancer Research 38(10): 3468-3473

Plasma estrogen and progesterone levels were determined in 77 premenopausal and 137 menopausal women at the same time that estradiol receptor (ER) and progesterone receptor (PGR) assays were carried out on their breast cancers. The frequency of ER and PGR is approximately the same in premenopausal and postmenopausal women, but the ER content is much higher in postmenopausal women. Although this is usually ascribed to the occupancy of receptors by endogenous estrogen in premenopausal women, our observations suggest that this is unlikely. The higher ER content in postmenopausal women is probably due to the fact that the cyclic progesterone increase in premenopausal women limits estrogen stimulation of ER synthesis. Our data suggest that the circulating levels of estrogen in postmenopausal women are sufficient to stimulate ER and PGR when ER is functional. In premenopausal women, on the other hand, high levels of circulating progesterone may inhibit PGR, and the absence of PGR in the breast cancers of premenopausal women should be interpreted warily if the plasma level of progesterone is unknown.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040052876

Download citation: RISBibTeXText

PMID: 688231

Related references

Estradiol and progesterone receptor levels in human breast cancer in relation to cytosol and plasma estrogen level. Journal of Steroid Biochemistry 18(4): 459-464, 1983

Estrogen and progesterone receptors in human breast cancer with concomitant assay of plasma 17beta-estradiol, progesterone, and prolactin levels. Cancer Research 39(5): 1834-1840, 1979

Estrogen and progesterone receptor levels in human breast cancer in relation to circulating sex hormone levels. Zhongguo Zhongliu Linchuang 19(1): 21-24, 1992

Estradiol and progesterone receptor levels in human breast carcinomas in relation to hormone serum levels in post menopausal women. Cancer Treatment Reports 63(7): 1185, 1979

Relation between estrogen and progesterone receptors tissue and plasma estradiol and progesterone in endometrial and breast cancer. Cancer Treatment Reports 63(7): 1189, 1979

Estradiol and progesterone receptor levels in breast carcinoma in relation to serum hormone levels in post menopausal women. Journal of Steroid Biochemistry 17(3): CI, 1982

Regulation of progesterone receptor messenger ribonucleic acid and protein levels in MCF-7 cells by estradiol: analysis of estrogen's effect on progesterone receptor synthesis and degradation. Endocrinology 122(3): 935-944, 1988

Estramustine binding site in human breast cancer biopsy samples. Its relation to estrogen and progesterone receptor levels, age and menopausal status. European Journal of Cancer and Clinical Oncology 23(10): 1505-1510, 1987

Plasma levels of 17alpha hydroxy progesterone related to progesterone and 17beta estradiol levels during normal menstrual cycles in women. Acta Endocrinologica Supplementum 155: 73, 1971

Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges. Oncotarget 6(32): 33146-33164, 2016

Correlation of estrogen beta-receptor messenger RNA with endogenous levels of plasma estradiol and progesterone in the female rat hypothalamus, the bed nucleus of stria terminalis and the medial amygdala. Brain Research. Molecular Brain Research 106(1-2): 30-41, 2002

Relation between receptor status and ultrastructure in breast cancer estrogen and progesterone receptor positive vs. estrogen and progesterone receptor negative. Pathology Research and Practice 181(4): 377-381, 1986

Relation between the levels of estrogen receptor and progesterone receptor and clinicopathological status in human endometrial carcinomas. Hua Xi Yi Ke Da Xue Xue Bao 22(1): 66-69, 1991

Regulation of estrogen receptor mrna levels and estrogen receptor dynamics in rat uterus by estradiol and progesterone. Biology of Reproduction 46(SUPPL 1): 63, 1992

Progesterone-binding protein in human myometrium. Binding site concentration in relation to endogenous progesterone and estradiol-17beta levels. Journal of Steroid Biochemistry 6(11-12): 1555-1561, 1975