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Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor

Horwitz, K.B.; McGuire, W.L.

Advances in Experimental Medicine and Biology 117: 95-110

1979


ISSN/ISBN: 0065-2598
PMID: 474293
Accession: 040053322

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We have provocative data which suggest that the nuclear estrogen-receptor complex interacts with DNA, that this interaction is required for appropriate receptor turnover or processing, and that processing may be essential for induction of a specific protein by estrogen. If the receptor is improperly inserted into DNA, as for instance when it is bound by nafoxidine, processing fails and the biological effect is blunted.

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