European collaborative trial of multifactorial prevention of coronary heart disease: final report on the 6-year results. World Health Organisation European Collaborative Group
Lancet 1(8486): 869-872
1986
ISSN/ISBN: 0140-6736
PMID: 2870351
Accession: 040059576
In a randomised controlled evaluation of multifactorial prevention of coronary heart disease (CHD) among 60 881 men employed in 80 factories in Belgium, Italy, Poland, and the UK intervention was associated with reductions of 10.2% in total CHD, 6.9% in fatal CHD, 14.8% in non-fatal myocardial infarction, and 5.3% in total deaths, with a neutral result for non-CHD deaths. Benefit was significantly related to the extent of risk factor change. The observed reduction in total CHD was 62% of that predicted by means of a multiple logistic function summary of risk factor changes. Advice on risk factor reduction in middle-aged men is effective to the extent that it is accepted and it appears to be safe.