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Evaluation of 1,3-pentadiene for mutagenicity by the Salmonella/mammalian microsome assay



Evaluation of 1,3-pentadiene for mutagenicity by the Salmonella/mammalian microsome assay



Mutation Research 157(1): 49-52



1,3-Pentadiene, a food contaminant produced by some molds when they metabolize sorbic acid, was tested for mutagenicity, using variations of the Salmonella/mammalian microsome assay. The chemical was incorporated into the test system (with and without S9 mix) by 3 methods: (a) the standard plate incorporation assay, (b) a liquid preincubation procedure and (c) exposure of test bacteria in the soft agar overlay to gaseous 1,3-pentadiene. The chemical was extremely toxic to the test bacteria with amounts as low as 2.0 microgram/plate causing cell death. However, none of the nonlethal concentrations tested by any of the methods was mutagenic to Salmonella typhimurium strains TA97, TA98, TA100, TA1535, TA1537 or TA1538.

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Accession: 040061280

Download citation: RISBibTeXText

PMID: 3892285

DOI: 10.1016/0165-1218(85)90048-5


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