EurekaMag.com logo
+ Translate

Evaluation of a real-time aerosol monitor (RAM-S) for inhalation studies


, : Evaluation of a real-time aerosol monitor (RAM-S) for inhalation studies. Fundamental and Applied Toxicology 10(2): 321-328

Measurement of the aerosol concentration in inhalation toxicology studies is generally done by gravimetric and/or chemical analysis of filter samples taken over a known period of time at a fixed sampling flow rate. The value obtained represents the time-averaged concentration in an exposure chamber. However, the filter method does not provide information as to the stability of aerosol concentration in "real-time" nor as to the time required for the aerosol concentration to reach the target value during the start-up of exposures. In order to accomplish evaluation of aerosol stability and chamber rise and fall times, a direct measurement device is required. An available real-time aerosol monitor (RAM-S, GCA Corp., Bedford, MA) is a photometer which collects scattered light from an aerosol cloud at a 70 +/- 25 degrees angle. The output signal is 0 to 10 volt with three ranges corresponding to maximum aerosol concentrations of 200, 20, and 2 mg/m3. The performance of the RAM-S was evaluated in inhalation studies involving nickel sulfate hexahydrate, nickel oxide, nickel subsulfide, and azodicarbonamide. Several RAM-S units were calibrated by obtaining both filter samples and voltage readings of a RAM-S simultaneously. Results indicated that the response of the RAM-S instruments was linear. However, the voltage output per given aerosol concentration was different for each compound used. Furthermore, there was interinstrument variability in the voltage response to aerosol concentration of a given compound. At concentrations higher than 100 mg/m3, modification of the flow system in the RAM-S was made to increase the sheath air around the optical system and also to dilute the aerosol concentration.

(PDF 0-2 workdays service)

Accession: 040062887

PMID: 3356319

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Cheng, Y.S.; Barr, E.B.; Benson, J.M.; Damon, E.G.; Medinsky, M.A.; Hobbs, C.H.; Goehl, T.J., 1988: Evaluation of a real time aerosol monitor ram s for inhalation studies. Measurement of the aerosol concentration in inhalation toxicology studies is generally done by gravimetric and/or chemical analysis of filter samples taken over a known period of time at a fixed sampling flow rate. The value obtained represents th...

Benton-Vitz, K.; Volckens, J., 2008: Evaluation of the pDR-1200 real-time aerosol monitor. The objective of this research was to characterize the ability of the pDR-1200 real-time aerosol monitor to measure aerosols of varying size, composition, and origin. Particle aspiration and transmission efficiency was characterized at airflow rat...

Budisulistiorini, S.Hapsari.; Canagaratna, M.R.; Croteau, P.L.; Marth, W.J.; Baumann, K.; Edgerton, E.S.; Shaw, S.L.; Knipping, E.M.; Worsnop, D.R.; Jayne, J.T.; Gold, A.; Surratt, J.D., 2014: Real-time continuous characterization of secondary organic aerosol derived from isoprene epoxydiols in downtown Atlanta, Georgia, using the Aerodyne Aerosol Chemical Speciation Monitor. Real-time continuous chemical measurements of fine aerosol were made using an Aerodyne Aerosol Chemical Speciation Monitor (ACSM) during summer and fall 2011 in downtown Atlanta, Georgia. Organic mass spectra measured by the ACSM were analyzed by...

Mayer L.; Dobey T.; Pingleton S., 1992: An evaluation with the aerosol inhalation monitor aim of experienced adult inhaler users. American Review of Respiratory Disease 145(4 PART 2): A475

Zhu, J.; Aikawa, B.; Pigeon, Ré., 2005: Measurement of fine particles in diesel emissions using a real-time aerosol monitor. A real-time monitoring methodology to determine diesel fine particles in diesel emissions has been evaluated. The range of particle size captured by the monitor was approximately 0.1 microm to 1 microm. DustTrak real-time monitors were connected t...

Oonishi M.; Hayakawa H., 1990: A new dust monitor for measurement of artificial beta aerosol activity concentration in real time. We have designed a new dust monitor that takes of advantage certain physical relationship that exist between the alpha and beta emissions of the radon and thoron progeny. This dust monitor is able to simultaneously measurement both alpha and beta...

Roy, C.J.; Hartings, J.M., 2003: An automated aerosol system that uses real-time dosimetry for inhalation exposures with primates. Toxicological Sciences 72(S-1): 296, March

Page S.J.; Jankowski R.A., 1984: Correlations between measurements with ram 1 real time aerosol monitor and gravimetric samplers on longwall shearer faces. Simultaneous AM-1 [real-time aerosol monitor] and gravimetric personal sampler respirable dust measurements were made by the Bureau of Mines [USA] at 2 locations adjacent to a moving shearer on longwall faces. These locations were 4.6-6.1 m (15-20...

Weber, R.J.; Orsini, D.; Ma, Y.; Sullivan, A.; Maxwell, K., 2002: Near real-time measurements of aerosol composition for studies of tropospheric aerosol chemistry From urban air quality to outflow of Asian plumes. Abstracts of Papers American Chemical Society 224(1-2): PHYS 367

Jiang, R-Ting.; Acevedo-Bolton, V.; Cheng, K-Chung.; Klepeis, N.E.; Ott, W.R.; Hildemann, L.M., 2011: Determination of response of real-time SidePak AM510 monitor to secondhand smoke, other common indoor aerosols, and outdoor aerosol. The amount of light scattered by airborne particles inside an aerosol photometer will vary not only with the mass concentration, but also with particle properties such as size, shape, and composition. This study conducted controlled experiments to...