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Evaluation of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis

Evaluation of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis

International Ophthalmology 13(3): 181-185

We investigated the effects of liposome-encapsulated clindamycin in Staphylococcus aureus endophthalmitis induced in rabbits. Clindamycin was encapsulated into liposomes, and suspended in two concentrations: 1 mg/0.1 ml and 2 mg/0.1 ml of clindamycin phosphate. Seven eyes received an intravitreal injection (0.1 ml volume) containing 1 mg of liposome-encapsulated clindamycin and seven eyes received 2 mg. Three control rabbits (six eyes) received drug-free liposomes (three eyes) and no treatment (three eyes). All but one eye treated with clindamycin recovered. All control eyes, including those treated with empty liposomes, were lost to infection.

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Accession: 040067117

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PMID: 2793311

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