EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of the effect of food on the absorption of sustained-release theophylline and comparison of two methods for serum theophylline analysis






Journal of Clinical Pharmacology 26(8): 638-642

Evaluation of the effect of food on the absorption of sustained-release theophylline and comparison of two methods for serum theophylline analysis

Fifteen healthy volunteers took part in a study to investigate the effect of food on the bioavailability of a slow-release formulation of theophylline. Serum theophylline levels were measured every two hours for ten hours after a single oral dose of 500 mg of theophylline. Serum levels were significantly higher after the dose was taken on an empty stomach; however, serum levels were significantly higher 10 hours later when the dose was taken after a standard meal. Despite these differences, eating had no overall effect on theophylline bioavailability. Two analytic methods for measuring serum levels of theophylline were compared, and it was found that fluorometry could measure lower levels and was therefore more precise than an enzyme immunoassay method, which is probably due to the complete automation and reduced interference of bilirubin and hemoglobin.


Accession: 040071477

PMID: 3793957

DOI: 10.1002/j.1552-4604.1986.tb02964.x



Related references

Delay in the absorption rate of theophylline from a sustained release theophylline preparation caused by food. British Journal of Clinical Pharmacology 12(6): 904-905, 1981

Comparison of serum theophylline levels in asthmatic children receiving sustained-release and rapid-release theophylline tablets. Israel Journal of Medical Sciences 18(2): 255-258, 1982

The effect of raising gastric pH with ranitidine on the absorption and elimination of theophylline from a sustained-release theophylline tablet. Pharmaceutical Research 8(12): 1516-1519, 1991

A new sustained-release theophylline suspension for asthmatic children: evaluation of serum theophylline concentrations. International Journal of Clinical Pharmacology Research 7(5): 345-350, 1987

The rise and fall of serum theophylline concentration: a comparison of sustained-release formulations in volunteers with rapid theophylline clearance. British Journal of Clinical Pharmacology 20(6): 589-596, 1985

Evaluation of circadian variation of serum theophylline levels in the sustained release theophylline treatment of chronic asthma. Japanese Journal of Allergology 35(7): 447-454, 1986

Comparison of circadian variation of serum theophylline concentration and bioavailability between Theo-dur tablet and a new sustained-release theophylline formulation (E-0686 granule). Arerugi 37(4): 218-225, 1988

The clinical effect of sustained-release theophylline (Theo-Dur) for asthmatic children and serum theophylline level. Arerugi 30(4): 190-196, 1981

Sustained-release theophylline preparations in asthmatic children. A short-term comparison of two products and the relationship of serum theophylline levels and pulmonary function changes. American Journal of Diseases of Children 140(4): 336-340, 1986

Circadian variation in the absorption of three sustained release theophylline products in asthmatic children and the effect of food on absorption of Somophyllin-CRT. British Journal of Clinical Practice. Supplement 35: 17-23, 1984