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Exploring delta-receptor function using the selective opioid antagonist naltrindole

Exploring delta-receptor function using the selective opioid antagonist naltrindole

Neuropharmacology 28(12): 1427-1430

Until recently the only pharmacological probes for delta-receptors have been peptide enkephalin analogues. These suffer from a number of limitations including high cost, partial agonist effects and a propensity for neurotoxicity. A stable non-peptide antagonist, naltrindole, has recently become available. We have explored its intrinsic actions and found that it attenuated swim stress-induced antinociception, a model for endogenous delta-receptor activation. Naltrindole may therefore be a useful alternative to presently available delta-receptor antagonists.

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Accession: 040104707

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PMID: 2559353

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