Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

Arai, H.; Nakao, K.; Saito, Y.; Sugawara, A.; Yamada, T.; Itoh, H.; Mukoyama, M.; Hosoda, K.; Shirakami, G.; Morii, N.

Journal of Hypertension. Suppl Official Journal of the International Society of Hypertension 6(4): S276-S278


ISSN/ISBN: 0952-1178
PMID: 2977162
DOI: 10.1097/00004872-198812040-00084
Accession: 040107334

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In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.