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Expression of common fragile sites on the X chromosome corresponds with active gene regions

Expression of common fragile sites on the X chromosome corresponds with active gene regions

Cancer Genetics and Cytogenetics 54(1): 71-76

The expression of common chromosomal fragile sites on human chromosomes has been proposed to be a cytogenetic expression of gene activity. Distinctive patterns of expression of two common fragile sites on the human X chromosome were observed in females. The fragile site at Xp22.31, located in a band region that contains genes which escape X inactivation, was expressed on both X chromosomes. By contrast, the fragile site at Xq22.1, in a region assumed to be subject to X inactivation, was expressed almost exclusively on one X, the active X chromosome. These findings provide evidence that common fragile site expression only occurs in regions with active genes.

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Accession: 040107761

Download citation: RISBibTeXText

PMID: 1905974

DOI: 10.1016/0165-4608(91)90032-p

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