+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of common fragile sites on the X chromosome corresponds with active gene regions



Expression of common fragile sites on the X chromosome corresponds with active gene regions



Cancer Genetics and Cytogenetics 54(1): 71-76



The expression of common chromosomal fragile sites on human chromosomes has been proposed to be a cytogenetic expression of gene activity. Distinctive patterns of expression of two common fragile sites on the human X chromosome were observed in females. The fragile site at Xp22.31, located in a band region that contains genes which escape X inactivation, was expressed on both X chromosomes. By contrast, the fragile site at Xq22.1, in a region assumed to be subject to X inactivation, was expressed almost exclusively on one X, the active X chromosome. These findings provide evidence that common fragile site expression only occurs in regions with active genes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040107761

Download citation: RISBibTeXText

PMID: 1905974

DOI: 10.1016/0165-4608(91)90032-p


Related references

Common fragile sites vs active gene sites a microdensitometric study. 1988

Common fragile sites on human chromosomes represent transcriptionally active regions: Evidence from camptothecin. Human Genetics 102(4): 409-414, 1998

Simultaneous expression of the rare and common fragile sites on the X chromosome. Clinical Genetics 40(6): 423-429, 1991

Common and rare fragile sites on human chromosomes. The cytogenetic expression of active and inactive genes?. Cancer Genetics and Cytogenetics 88(2): 184-185, 1996

Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints. International Journal of Cancer 120(1): 48-54, 2006

Spontaneous fragile x chromosomes in routine amniotic fluid culture the x chromosome common fragile site x q272 mistaken for the fragile x chromosome x q273. Pediatric Research 27(4 PART 2): 136A, 1990

Chromosome fragile sites in Arabidopsis harbor matrix attachment regions that may be associated with ancestral chromosome rearrangement events. Plos Genetics 8(12): E1003136-E1003136, 2013

How common are common fragile sites: Variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus). Human Genetics 100(2): 182-188, 1997

How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites. Cytogenetic and Genome Research 101(1): 8-16, 2003

Expression of fragile sites on chromosome 11q13 is an early event during head and neck tumorigenesis, preceding gene amplification. Proceedings of the American Association for Cancer Research Annual Meeting 40: 689, March, 1999

Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites. Molecular Cancer Research 3(3): 130-138, 2005

Common fragile sites as targets for chromosome rearrangements. Dna Repair 5(9-10): 1126-1135, 2006