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Expression of mRNA for Gs alpha and Gi2 alpha in primary cultured mouse cerebral cortical neurons



Expression of mRNA for Gs alpha and Gi2 alpha in primary cultured mouse cerebral cortical neurons



Neuroreport 2(12): 766-768



Developmental changes of mRNAs for alpha-subunits of GTP binding protein (G-protein) such as Gs alpha and Gi2 alpha during neuronal development were examined in both primary cultured cerebral cortical neurons and cerebral cortices obtained from age-matched mice. The expression of mRNAs for both G-protein alpha-subunits in primary cultured neurons showed a development pattern similar to that in the cerebral cortex in vivo. Both mRNAs were expressed at an early stage of neuronal development, and the expression patterns of mRNA for both G-protein alpha-subunits were found to be only slightly changed during development. These results suggest that the G-protein appears at an early stage of neuronal development and may play an important role therein.

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Accession: 040108769

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PMID: 1724387


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