+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of natural killer cell markers in non-Hodgkin's lymphomas

Expression of natural killer cell markers in non-Hodgkin's lymphomas

Human Pathology 18(12): 1257-1262

One hundred forty-nine cases of non-Hodgkin's lymphoma were studied with a panel of monoclonal antibodies, including antibodies to natural killer (NK) cells--anti-NKH1, anti-Leu 7, and anti-Leu 11b. There were 95 B-cell, 51 T-cell, and three null cell lymphomas. Seventeen T-cell lymphomas (33 per cent) expressed NKH1, Leu 7, and/or Leu 11b. None of the B- or null cell lymphomas expressed the NK markers. In comparison with the NK-negative T-cell lymphomas, the NK-positive cases showed a predilection for the nasal and paranasal region. There was a more significant loss of the T-cell markers T3 (peripheral T cell) and T4 (T-helper cell) in NK-positive lymphomas. The difference was due to a high proportion of nasal/paranasal lymphomas, which were associated with a frequent loss of T-cell markers, among the NK-positive cases. However, a similar degree of loss of T-cell markers was observed among NK-positive and NK-negative nasal/paranasal lymphomas. We conclude that expression of NK markers occurs exclusively in a proportion of T-cell lymphomas, but not B-cell or null cell lymphomas. The reason this occurs predominantly in nasal and paranasal lymphomas is unknown.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 040108991

Download citation: RISBibTeXText

PMID: 3500108

DOI: 10.1016/s0046-8177(87)80410-0

Related references

Human interleukin-10 expression in T/natural killer-cell lymphomas: association with anaplastic large cell lymphomas and nasal natural killer-cell lymphomas. American Journal of Pathology 153(4): 1229-1237, 1998

Expression of adult and fetal natural killer cell markers in sinonasal lymphomas. Blood 83(8): 2255-2260, 1994

Intestinal T-cell and natural killer-cell lymphomas in Taiwan with special emphasis on 2 distinct cellular types: natural killer-like cytotoxic T cell and true natural killer cell. Human Pathology 39(7): 1018-1025, 2008

Epstein-Barr virus in T and natural killer (NK) cell non-Hodgkin's lymphomas. Leukemia 10(Suppl. 2): S84-S87, 1996

Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas. Journal of Pathology 183(4): 432-439, 1997

Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions. Oncoimmunology 4(8): E1026503, 2015

Azurophilic granules in lymphomas immunoreactive for natural killer cell markers. American Journal of Clinical Pathology 94(1): 120, 1990

Interleukin-15 affects patient survival through natural killer cell recovery after autologous hematopoietic stem cell transplantation for non-Hodgkin lymphomas. Clinical and Developmental Immunology 2010: 914945, 2010

Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas. Journal of Pathology 202(1): 60-69, 2004

Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas. Acta Histochemica et Cytochemica 44(3): 119-131, 2011

Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or Tgammadelta phenotype, anaplastic morphology and CD30 expression. Leukemia and Lymphoma 38(3-4): 317-326, 2000

Correlation of cytotoxic function with the expression of natural killer cell markers CD69, killer inhibitory receptors , and cytoplasmic perforin and IFNgamma. Clinical Science (London) 104(Suppl. 49): 52P, 2003

Natural killer like cells in non-Hodgkin lymphomas. British Journal of Haematology 64(4): 850-851, 1986

Differential Emu enhancer activity and expression of BOB1/OBF1, Oct2, PU1 and immunglobulin in reactive B-cell populations, non-Hodgkin lymphomas and Hodgkin lymphomas. Pathology Research and Practice 199(4): 269, 2003

Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas. Human Pathology 40(12): 1731-1737, 2009