Section 41
Chapter 40,113

Extra-adrenal pheochromocytoma-ganglioneuroma. A case report

Yoshimi, N.; Tanaka, T.; Hara, A.; Bunai, Y.; Kato, K.; Mori, H.

Pathology Research and Practice 188(8): 1098


ISSN/ISBN: 0344-0338
PMID: 1300605
DOI: 10.1016/s0344-0338(11)81261-6
Accession: 040112962

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A case of rare extra-adrenal tumor composed of pheochromocytoma-ganglioneuroma which developed in a 48-year-old Japanese male is reported. Histologically, the tumor contained equal proportion of two distinct patterns, pheochromocytoma and ganglioneuroma. Immunohistochemical examination revealed that pheochromocytoma cells were positive for Leu-7 and ganglion cells in ganglioneuroma were positive for vasoactive intestinal peptide (VIP), respectively. Neuron specific enolase (NSE) was positive in the neoplastic cells of both components, and S-100 protein was also positive in fibers around ganglion cells. Ultrastructural examination revealed that neurosecretory granules were present in the neoplastic cells.

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