+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Failure of interferon to prevent recurrent hepatitis B infection in hepatic allograft



Failure of interferon to prevent recurrent hepatitis B infection in hepatic allograft



Mayo Clinic Proceedings 64(4): 429-432



Chronic liver disease associated with hepatitis B virus infection is both common and serious; no satisfactory treatment currently exists. Orthotopic liver transplantation is an option for patients with end-stage liver disease associated with hepatitis B virus infection despite the risk of allograft reinfection. Passive immunoprophylaxis has been attempted perioperatively to prevent graft infection but has not been beneficial. Some patients with chronic type B hepatitis have benefited clinically from antiviral therapy and, in particular, interferon, but its use has not previously been reported as an approach to prevent allograft infection. We administered recombinant leukocyte A interferon perioperatively to a patient who underwent liver transplantation for type B chronic active hepatitis and cirrhosis. Circulating hepatitis B virus DNA was found postoperatively while the patient was receiving interferon, and stainable viral antigen subsequently reappeared in the transplanted liver. Thus, the drug failed to prevent viral replication and allograft infection. Thus far, no evidence of progression of the chronic hepatitis has been noted.

(PDF emailed within 0-6 h: $19.90)

Accession: 040125173

Download citation: RISBibTeXText

PMID: 2654499

DOI: 10.1016/S0025-6196(12)65733-4


Related references

Failure of interferon to prevent recurrent hepatitis b infection in hepatic allograft. Hepatology 8(5): 1287, 1988

Recurrent hepatitis B infection in hepatic allograft. Mayo Clinic Proceedings 64(5): 597-597, 1989

Long-term application of human polyclonal hepatitis-B immunoglobulin to prevent hepatic allograft infection. Netherlands Journal of Medicine International Edition 43(1-2): 74-82, 1993

Follow-up of recurrent hepatitis B and delta infection in liver allograft recipients after treatment with recombinant interferon-alpha. Journal of Hepatology 13(3): 339-346, 1991

Failure of ganciclovir prophylaxis to prevent allograft reinfection following orthotopic liver transplantation for chronic hepatitis B infection. Liver Transplantation and Surgery 2(5): 370-374, 1996

Long-term application of human polyclonal hepatitis-B immunoglobulin to prevent hepatic allograft infection. A review of the literature and presentation of five cases. Netherlands Journal of Medicine 43(1-2): 74-82, 1993

Factors that identify survival after liver retransplantation for allograft failure caused by recurrent hepatitis C infection. Liver Transplantation 10(12): 1497-1503, 2004

Recurrent hepatitis C infection following orthotopic liver transplantation is predicted by posttransplant serum and hepatic allograft viral titers. Transplantation Proceedings 29(7): 2839-2840, 1997

Clinical outcome and pathological correlation following interferon alpha 2B treatment of recurrent hepatitis B and hepatitis C in orthotopic liver allograft recipients. Hepatology 20(4 PART 2): 130A, 1994

Follow up of recurrent hepatitis b and delta in liver allograft recipients treated with interferon alpha. Journal of Hepatology 11(SUPPL 2): S35, 1990

De novo hepatocellular carcinoma in a hepatic allograft with recurrent hepatitis C cirrhosis. Liver Transplantation and Surgery 5(1): 81-82, 1999

Failure of interferon to prevent disease progression and liver cancer in hepatitis C virus infection: proof of absence or absence of proof?. Gastroenterology 138(2): 777-779, 2009

Early treatment of acute hepatitis C infection with monotherapy interferon alfa is effective to prevent development of chronic hepatitis. Gastroenterology 120(5 Supplement 1): A 380-A 381, April, 2001

The influence of hepatitis B and hepatitis C virus infection in the recipient on late renal allograft failure. Nephrology, Dialysis, Transplantation 19 Suppl 3: Iii72-6, 2004

Failure of acyclovir to prevent cytomegalovirus infection in renal allograft recipients. Transplant International 6(5): 285-289, 1993