Section 41
Chapter 40,167

Formulation and in vitro-in vivo evaluation of sustained-release lithium carbonate tablets

Ciftçi, K.; Capan, Y.; Oztürk, O.; Hincal, A.A.

Pharmaceutical Research 7(4): 359-363


ISSN/ISBN: 0724-8741
PMID: 2114020
DOI: 10.1023/a:1015863204732
Accession: 040166454

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The release of lithium carbonate incorporated into polymethylmethacrylate, polyvinyl chloride, hydrogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability.

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