+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Free level monitoring of carbamazepine and valproic acid: clinical significance

Free level monitoring of carbamazepine and valproic acid: clinical significance

Clinical Neuropharmacology 8(4): 362-371

The recently available ultrafiltration technique facilitates determination of the free drug serum concentration of several antiepileptic drugs. For this reason a reappraisal of the clinical significance of free level monitoring was thought necessary. In this study on 203 patients receiving carbamazepine monotherapy and 101 patients receiving valproic acid monotherapy, the total and free drug levels were correlated with therapeutic outcome and side effects. Our investigations indicated no closer correlation between free concentration and seizure reduction or side effects than between total concentration and effectiveness or side effects. However, we found a close correlation between total and free concentrations.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040171098

Download citation: RISBibTeXText

PMID: 3935312

Related references

Free level monitoring of carbamazepine and valproic acid. Wolf, P , Et Al (Ed ) Advances in Epileptology; Xvith Epilepsy International Symposium, Hamburg, West Germany, September 6-9, 1985 Xxviii+787p Raven Press: New York, New York, Usa Illus 439-444, 1987

Filtration for free drug level monitoring: carbamazepine and valproic acid. Therapeutic Drug Monitoring 6(1): 67-76, 1984

Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid. Folia Medica 42(3): 16-19, 2001

Prediction of the free serum concentrations of phenytoin phenobarbital carbamazepine and carbamazepine 10 11 epoxide in patients on valproic acid co medication. Sunshine, I (Ed ) Recent Developments in Therapeutic Drug Monitoring And Clinical Toxicology; Second International Conference on Tdm (Therapeutic Drug Monitoring)-Toxicology, Barcelona, Spain Xii+791p Marcel Dekker, Inc : New York, New York, Usa; Basel, Switzerland Illus 401-407, 1992

The clinical value of free drug level monitoring in patients on monotherapy with carbamazepine phenytoin or sodium valproate. Acta Therapeutica 12(4): 337-352, 1986

A LC-MS/MS method for therapeutic drug monitoring of carbamazepine, lamotrigine and valproic acid in DBS. Bioanalysis 7(16): 2031-2039, 2016

Effect of heating human sera at a temperature necessary to deactivate human immunodeficiency virus on measurement of free phenytoin, free valproic acid, and free carbamazepine concentrations. Therapeutic Drug Monitoring 21(4): 421-425, 1999

Therapeutic carbamazepine (Cbz) and valproic acid (Vpa) monitoring in children using saliva as a biologic fluid. Journal of Epilepsy and Clinical Neurophysiology 14(2): 55-58, 2008

Fluorescence polarization immunoassay for the monitoring of phenytoin pheno barbital carbamazepine and valproic acid. American Journal of Clinical Pathology 77(2): 238, 1982

Prediction of free levels of phenytoin and carbamazepine in patients comedicated with valproic acid. Therapeutic Drug Monitoring 17(4): 327-332, 1995

Three new assays for monitoring serum carbamazepine, phenytoin and valproic acid on the IMMULITE automated immunoassay analyzer. Clinical Chemistry 45(6 PART 2): A121, 1999

Evaluating appropriateness of digoxin, carbamazepine, valproic acid, and phenytoin usage by therapeutic drug monitoring. Clinical Laboratory 59(3-4): 325-331, 2013

Significance of free phenytoin level measurement in epileptic patients receiving concurrent treatment with phenytoin and valproic acid. Journal of Tokyo Women's Medical College 56(10-11): 991-997, 1986

Valproic acid-carbamazepine interaction: is valproic acid a selective inhibitor of epoxide hydrolase?. Therapeutic Drug Monitoring 17(3): 217-220, 1995

Estimation vs determination of fraction of free drug of phenytoin , valproic acid and carbamazepine in patients on monotherapy. Clinical Chemistry & Laboratory Medicine 37(SPEC SUPPL ): S317, 1999