Section 41
Chapter 40,194

Gangliosides in SV-40-transformed cells derived from Tay-Sachs disease fetal brain

Hoffman, L.M.; Brooks, S.E.; Stein, M.R.; Adachi, M.; Schneck, L.

Metabolic Brain Disease 4(2): 87-93


ISSN/ISBN: 0885-7490
PMID: 2547146
DOI: 10.1007/bf00999386
Accession: 040193541

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A human glial brain cell line derived from a Tay-Sachs disease fetal cerebellum was transformed with SV-40 virus in order to obtain a transformed brain cell line which reflected the characteristics of the disease. It was shown that the transformed TSD cell line maintained an elevated level of GM2 which was similar to that shown by the nontransformed precursor. In addition, the TSD transformed line lacked hexosaminidase A.

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