Gastric secretory response to cholinergic stimulation in rats chronically pretreated with pentagastrin or histamine in depot form

Kowalewski, K.

Digestion 14(4): 368-371


ISSN/ISBN: 0012-2823
PMID: 964477
DOI: 10.1159/000197954
Accession: 040196902

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Rats pretreated by daily depot injections of pentagastric for 24 days, responded with a significant increase of gastric secretion volume, and HC1 concentration and output, when infused intravenously with bethanechol chloride. In these rats, the total weight of the stomach and the height of the fundic mucosa were also increased. Pretreatment with histamine had no effect on rat gastric tissue or gastric secretion, under identical conditions of stimulation.