+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Gastroduodenal mucosal injury during hepatic arterial infusion of chemotherapeutic agents. Lack of cytoprotection by prostaglandin E1 analogue



Gastroduodenal mucosal injury during hepatic arterial infusion of chemotherapeutic agents. Lack of cytoprotection by prostaglandin E1 analogue



Gastroenterology 92(3): 566-569



Eighteen colorectal cancer patients with liver metastases receiving hepatic arterial infusion of chemotherapeutic agents (mitomycin-C + 5-FUDR) were randomized to receive misoprostol (a prostaglandin E1 analogue) or placebo as a mode of cytoprotection against inadvertent gastroduodenal mucosal injury. Four of 10 patients on misoprostol and 3 of 8 patients on placebo developed gastroduodenal mucosal injury (p greater than 0.1), which was confirmed by endoscopy. Significant tumor responses to chemotherapy were equally distributed between the two groups. Although our sample size was small and type II error (false-negative trial) cannot be excluded, these data strongly suggest that prophylaxis with misoprostol does not prevent the acute gastroduodenal mucosal injury associated with hepatic arterial infusion of chemotherapeutic agents.

(PDF emailed within 1 workday: $29.90)

Accession: 040197659

Download citation: RISBibTeXText

PMID: 2950015


Related references

Gastroduodenal mucosal injury during hepatic arterial infusion of chemotherapeutic agents. Gastroenterology 92(3): 566-569, 1987

Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice. Laboratory Investigation 80(3): 371-377, 2000

Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine. Cancer 73(8): 2042-2047, 1994

Effect of intraarterial Solcoseryl on gastroduodenal mucosal lesions occurring after treatment of malignant abdominal tumors with transcatheter arterial occlusion and intraarterial infusion of anticancer agents. Yunoki, K Current Clinical Practice Series; Cytoprotection and cytobiology, Vol 9: 96-101, 1992

Gastric mucosal injury after hepatic arterial infusion chemotherapy with floxuridine. A clinical and pathologic study. Cancer 73(8): 2042-2047, 1994

Prostaglandin e 2 cytoprotection in aspirin induced gastric mucosal injury an endoscopic study. American Journal of Gastroenterology 74(1): 93, 1980

Prostaglandin cytoprotection against ethanol induced injury of isolated gastric mucosal cells. Gastroenterology 82(5 PART 2): 1122, 1982

Role of gastric mucosal extracellular matrix in alcohol injury and prostaglandin cytoprotection. Gastroenterology 94(5 PART 2): A409, 1988

Effect of zy 15029 on absolute ethanol induced gastric mucosal injury cytoprotection without prostaglandin. Clinical Research 34(1): 30A, 1986

Prostaglandin cytoprotection effect on histologic and micro circulatory changes in alcohol induced gastric mucosal injury. Allen, A Et Al (Ed ) Mechanisms Of Mucosal Protection in The Upper Gastrointestinal Tract; Proceedings Of An International Conference, Manchester, England, Apr 1983 Xxi+392p Raven Press: New York, N Y , Usa Illus P285-286, 1984

Hepatic Outflow Occlusion During Hepatic Artery Infusion With Chemotherapeutic Agents. Cancer 17: 1579-1585, 1964

Extra- and intra-hepatic metastasis successfully treated with alternative chemotherapy with hepatic arterial infusion and systemic intravenous infusion after responding to hepatic metastasis from colon cancer by hepatic arterial infusion--a case report. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 34(12): 1976-1978, 2008

Gastroduodenal ulceration after hepatic arterial infusion chemotherapy. Ajr. American Journal of Roentgenology 136(6): 1216-1218, 1981

Splenic or hepatic arterial injections of interleukin-2 with chemotherapeutic agents for hepatic metastases. Nihon Geka Gakkai Zasshi 92(9): 1229-1233, 1991

Tissue levels of chemotherapeutic agents for hepatic metastasis during hepatic arterial and portal injection. In Vivo 13(2): 195-198, 1999