+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Genetic control of antibody responses to PHA in inbred rats



Genetic control of antibody responses to PHA in inbred rats



Scandinavian Journal of Immunology 5(10): 1149-1153



Phytohemagglutinin (PHA-P; Difco) contains four immunogenic components. The antibody response in rats to two of these components is shown to be genetically determined: AS rats are high responders and BN rats are low responders to both antigens. Responsiveness to the two components segregates independently as autosomal, dominant traits in a manner that is compatible with a one-gene hypothesis for both responses. The antibody response to the mitogenic fraction of PHA segregates together with the in vitro mitogenic response to PHA and to other mitogens. These responses are not linked to the major histocompatibility complex (MHC) of the rat. The antibody response to a nonmitogenic fraction from PHA is, however, linked to the MHC.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040205975

Download citation: RISBibTeXText

PMID: 1013649

DOI: 10.1111/j.1365-3083.1976.tb00256.x


Related references

Genetic control of antibody forming cells and antibody in inbred rats. Federation Proceedingspart 1: 996, 1973

The genetic control of the antibody response in inbred rats. Molecular and Cellular Biochemistry 7(3): 145-156, 1975

Genetic control of the antibody response in inbred rats. Journal of Immunogenetics 1(4): 265-275, 1974

Genetic control of reaginic antibody synthesis in inbred rats. Journal of Allergy & Clinical Immunology 55(2): 109, 1975

Genetic control of reaginic antibody synthesis in inbred bn rats. Federation Proceedingspart 1: 774, 1974

The genetic control of antibody binding constants and specificities in inbred rats. Journal of Immunology 113(5): 1468-1476, 1974

Genetic control of b cell function 1. 2 genes determine the magnitude of antibody responses of inbred mice to red blood cells. Immunobiology 160(5): 454-471, 1982

Genetic control of serum antibody responses of inbred mice to type 1 and type 2 fimbriae from Actinomyces viscosus T14V. Infection and Immunity 59(7): 2364-2369, 1991

Genetic control of B cell function. II. Antibody responses of inbred mice to red blood cells are controlled at the B cell level. Journal of Immunology 127(6): 2512-2516, 1981

Reagin synthesis in inbred rats: II. Genetic control of reaginic antibody synthesis. Journal of Allergy and Clinical Immunology 58(3): 381-386, 1976

Genetic control of antibody responses to Moloney virus in rats. Leukemia Research 6(1): 127-129, 1982

Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses. Journal of Immunology 117(4): 1079-1084, 1976

Effects of age and genetic background on the antibody response in inbred rats. Gerontologia 20(2): 88, 1974

Genetic control of the antibody response in inbred mice. J. exp. Med 128: 1-11, 1968

Mast cell and anaphylactic antibody responses in inbred rats to syngeneic fibrosarcomas. International Archives of Allergy and Applied Immunology 49(5): 627-631, 1975